产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13595, RRID:AB_2846614.
展开/折叠
ba1; Beta 1 globin; beta globin; beta globin chain; BETA GLOBIN TYPE; BETA THALASSEMIAS; Beta-A1-globin; CD113t C; CD113t-C; ERYTHREMIA; HBB; Hemoglobin beta 1 chain; hemoglobin beta chain; hemoglobin beta chain complex; Hemoglobin beta chain, major form; HEMOGLOBIN BETA LOCUS; Hemoglobin beta-1 chain; Hemoglobin subunit beta-1; METHEMOGLOBINEMIA;
抗原和靶标
- P68871 HBB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P68871 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| K9 | Acetylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| K18 | Acetylation | Uniprot | |
| Y36 | Phosphorylation | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S50 | O-Glycosylation | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| T51 | Phosphorylation | Uniprot | |
| K60 | Acetylation | Uniprot | |
| K62 | Acetylation | Uniprot | |
| K66 | Acetylation | Uniprot | |
| S73 | O-Glycosylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K83 | Acetylation | Uniprot | |
| T85 | O-Glycosylation | Uniprot | |
| T88 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| C94 | S-Nitrosylation | Uniprot | |
| C113 | S-Nitrosylation | Uniprot | |
| K121 | Acetylation | Uniprot | |
| T124 | Phosphorylation | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| K133 | Acetylation | Uniprot | |
| K145 | Acetylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot |
研究背景
Involved in oxygen transport from the lung to the various peripheral tissues.
LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.
S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).
Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure.
Red blood cells.
Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.
Belongs to the globin family.
研究领域
· Human Diseases > Infectious diseases: Parasitic > African trypanosomiasis.
· Human Diseases > Infectious diseases: Parasitic > Malaria.
限制条款
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