PRDM2 Antibody - #DF13607

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产品: PRDM2 抗体
货号: DF13607
描述: Rabbit polyclonal antibody to PRDM2
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine
分子量: 188kDa; 189kD(Calculated).
蛋白号: Q13029
RRID: AB_2846626

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%)
克隆:
Polyclonal
特异性:
PRDM2 Antibody detects endogenous levels of total PRDM2.
RRID:
AB_2846626
引用格式: Affinity Biosciences Cat# DF13607, RRID:AB_2846626.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

GATA 3 binding protein G3B; GATA-3-binding protein G3B; HUMHOXY1; Lysine N methyltransferase 8; Lysine N-methyltransferase 8; MTB ZF; MTB-ZF; MTE binding protein; MTE-binding protein; PR domain containing 2 with ZNF domain; PR domain containing protein 2; PR domain zinc finger protein 2; PR domain-containing protein 2; PRDM2; PRDM2_HUMAN; Retinoblastoma protein binding zinc finger protein; Retinoblastoma protein interacting zinc- inger protein; Retinoblastoma protein-interacting zinc finger protein; RIZ; RIZ-LSB; RIZ1; RIZ2; Zinc finger DNA binding protein; Zinc finger protein RIZ;

抗原和靶标

免疫原:
Uniprot:

Q13029(PRDM2_HUMAN) >>Visit HPA database.

基因/基因ID:
PRDM2(7799)
表达:
Q13029 PRDM2_HUMAN:

Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.

序列:
MNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAACEVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLEEPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHIHISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVASKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVTEDLPKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPPCFDEYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSEGKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAEIKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPIRMAKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRFNIKSRERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFSYSLRLASRCSPPAAPYITRQYRKVKAPAAAQFQGPFFKE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Xenopus
75
Horse
0
Sheep
0
Dog
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q13029 作为底物

Site PTM Type Enzyme
T47 Phosphorylation
K63 Ubiquitination
T198 Phosphorylation
S199 Phosphorylation
S421 Phosphorylation
T423 Phosphorylation
S427 Phosphorylation
S447 Phosphorylation
S471 Phosphorylation
R508 Methylation
R516 Methylation
K626 Ubiquitination
T641 Phosphorylation
S643 Phosphorylation
K700 Ubiquitination
T702 Phosphorylation
S720 Phosphorylation
T737 Phosphorylation
S738 Phosphorylation
S739 Phosphorylation
S742 Phosphorylation
S743 Phosphorylation
S747 Phosphorylation
K774 Ubiquitination
S781 Phosphorylation
S785 Phosphorylation
S796 Phosphorylation
S846 Phosphorylation
S876 Phosphorylation
T885 Phosphorylation
Y896 Phosphorylation
T910 Phosphorylation
S912 Phosphorylation
S914 Phosphorylation
S1054 Phosphorylation
S1055 Phosphorylation
S1056 Phosphorylation
S1057 Phosphorylation
S1118 Phosphorylation
S1141 Phosphorylation
T1255 Phosphorylation
S1256 Phosphorylation
S1265 Phosphorylation
S1266 Phosphorylation
Y1295 Phosphorylation
S1297 Phosphorylation
S1359 Phosphorylation
S1414 Phosphorylation
K1425 Acetylation
K1431 Acetylation
S1484 Phosphorylation
S1491 Phosphorylation
S1509 Phosphorylation
S1511 Phosphorylation
T1529 Phosphorylation
S1571 Phosphorylation
T1585 Phosphorylation
K1597 Ubiquitination
K1606 Ubiquitination
S1641 Phosphorylation
S1645 Phosphorylation
S1652 Phosphorylation

研究背景

功能:

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.

亚基结构:

Binds to the retinoblastoma protein (RB). Interacts with GATA3.

蛋白家族:

Belongs to the class V-like SAM-binding methyltransferase superfamily.

研究领域

· Metabolism > Amino acid metabolism > Lysine degradation.

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