产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13612, RRID:AB_2846631.
展开/折叠
5''-cyclic nucleotide phosphodiesterase 1C; Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C; Calcium/calmodulin-dependent 3''; Cam PDE 1C; Cam-PDE 1C; hCam 3; hCam-3; HCAM3; HSPDE1C1A; Human 3'5' cyclic nucleotide Phosphodiesterase; PDE 1C; Pde1c; PDE1C_HUMAN; Phosphodiesterase 1C; Phosphodiesterase 1C calmodulin dependent; Phosphodiesterase 1C calmodulin dependent 70kDa;
抗原和靶标
Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle (PubMed:8557689). Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung (PubMed:8557689). Also expressed at low levels in uterus and testis (PubMed:8557689).
- Q14123 PDE1C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14123 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| T5 | Phosphorylation | Uniprot | |
| Y18 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| T194 | Phosphorylation | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| T438 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| Y503 | Phosphorylation | Uniprot | |
| S505 | Phosphorylation | Uniprot | |
| K695 | Methylation | Uniprot |
研究背景
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle. Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung. Also expressed at low levels in uterus and testis.
Homodimer.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Sensory system > Taste transduction.
· Organismal Systems > Endocrine system > Renin secretion.
限制条款
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