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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13634, RRID:AB_2846653.
展开/折叠
FLJ20992; FLJ90230; Hedgehog interacting protein; Hedgehog-interacting protein; hedgehoginteracting protein; HHIP; HHIP_HUMAN; Hip;
抗原和靶标
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
- Q96QV1 HHIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96QV1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K93 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| N447 | N-Glycosylation | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| Y616 | Phosphorylation | Uniprot | |
| T618 | Phosphorylation | Uniprot | |
| T620 | Phosphorylation | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| K659 | Ubiquitination | Uniprot |
研究背景
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Cell membrane>Peripheral membrane protein. Secreted.
Note: The last 22 C-terminal amino acids may participate in cell membrane attachment.
Cytoplasm.
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
Interacts with all three hedgehog family members, SHH, IHH and DHH.
A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.
Belongs to the HHIP family.
研究领域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma. (View pathway)
文献引用
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