| 产品: | Dynorphin A 抗体 |
| 货号: | DF13654 |
| 描述: | Rabbit polyclonal antibody to Dynorphin A |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 28kDa; 28kD(Calculated). |
| 蛋白号: | P01213 |
| RRID: | AB_2846673 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13654, RRID:AB_2846673.
展开/折叠
ADCA; Alpha neoendorphin; Beta neoendorphin; Beta-neoendorphin-dynorphin; Big Dyn; Big dynorphin; Dyn; Dyn-A17; Dyn-B; Dynorphin A; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8); Dynorphin B; Dynorphin B(1-13); Dynorphin B-29; Enkephalin B; Leu enkephalin; Leumorphin; Neoendorphin dynorphin enkephalin prepropeptide; PDYN; PDYN_HUMAN; PENKB; Preprodynorphin; Preproenkephalin B; Prodynorphin; Proenkephalin B; Rimorphin; SCA23;
抗原和靶标
- P01213 PDYN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P01213 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S101 | Phosphorylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K118 | Acetylation | Uniprot |
研究背景
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Secreted.
Belongs to the opioid neuropeptide precursor family.
研究领域
· Human Diseases > Substance dependence > Cocaine addiction.
· Human Diseases > Substance dependence > Amphetamine addiction.
· Human Diseases > Substance dependence > Alcoholism.
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