| 产品: | HB EGF 抗体 |
| 货号: | DF13666 |
| 描述: | Rabbit polyclonal antibody to HB EGF |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 23kDa; 23kD(Calculated). |
| 蛋白号: | Q99075 |
| RRID: | AB_2846685 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13666, RRID:AB_2846685.
展开/折叠
diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF; HBEGF_HUMAN; HEGFL; Heparin binding EGF like growth factor; Heparin binding epidermal growth factor; Heparin binding epidermal growth factor like growth factor; Heparin-binding EGF-like growth factor; Proheparin binding EGF like growth factor;
抗原和靶标
- Q99075 HBEGF_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q99075 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T37 | O-Glycosylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| S38 | O-Glycosylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| T44 | O-Glycosylation | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| T47 | O-Glycosylation | Uniprot | |
| T75 | O-Glycosylation | Uniprot | |
| S77 | O-Glycosylation | Uniprot | |
| S78 | O-Glycosylation | Uniprot | |
| T85 | O-Glycosylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K99 | Acetylation | Uniprot | |
| K103 | Acetylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| S207 | Phosphorylation | Uniprot |
研究背景
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.
Secreted>Extracellular space.
Note: Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Cell membrane>Single-pass type I membrane protein.
Interacts with FBLN1 (By similarity). Interacts with EGFR and ERBB4.
研究领域
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Infectious diseases: Bacterial > Epithelial cell signaling in Helicobacter pylori infection.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Specific types > Bladder cancer. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
限制条款
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