| 产品: | AADACL1 抗体 |
| 货号: | DF13688 |
| 描述: | Rabbit polyclonal antibody to AADACL1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 45kDa; 46kD(Calculated). |
| 蛋白号: | Q6PIU2 |
| RRID: | AB_2846707 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13688, RRID:AB_2846707.
展开/折叠
Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase;
抗原和靶标
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
- Q6PIU2 NCEH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6PIU2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T85 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| T240 | Phosphorylation | Uniprot | |
| N287 | N-Glycosylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot |
研究背景
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
N-glycosylated.
Membrane>Single-pass type II membrane protein. Microsome.
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
Belongs to the 'GDXG' lipolytic enzyme family.
研究领域
· Organismal Systems > Digestive system > Cholesterol metabolism.
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