| 产品: | SEC61A 抗体 |
| 货号: | DF13740 |
| 描述: | Rabbit polyclonal antibody to SEC61A |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 52kDa; 52kD(Calculated). |
| 蛋白号: | P61619 |
| RRID: | AB_2846759 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13740, RRID:AB_2846759.
展开/折叠
chunp6898; fb62c11; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; Protein transport protein Sec61 subunit alpha isoform 1; S61A1_HUMAN; SEC 61; SEC 61A; Sec61 alpha 1; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha-1; SEC61; Sec61 homolog; SEC61A1; sec61aa;
抗原和靶标
- P61619 S61A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P61619 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Ubiquitination | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| T86 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| R273 | Methylation | Uniprot | |
| Y276 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| T407 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot |
研究背景
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Expressed in proximal and distal tubules in kidney (at protein level).
The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.
Belongs to the SecY/SEC61-alpha family.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Genetic Information Processing > Folding, sorting and degradation > Protein export.
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Vibrio cholerae infection.
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