| 产品: | KCNQ3 抗体 |
| 货号: | DF13741 |
| 描述: | Rabbit polyclonal antibody to KCNQ3 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 96kDa; 97kD(Calculated). |
| 蛋白号: | O43525 |
| RRID: | AB_2846760 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13741, RRID:AB_2846760.
展开/折叠
BFNC 2; BFNC; BFNC2; EBN 2; EBN2; KCNQ 3; KCNQ3; KCNQ3_HUMAN; KQT like 3; KQT-like 3; KV7.3; Potassium channel subunit alpha KvLQT3; Potassium channel voltage gated subfamily Q member 3; Potassium voltage gated channel KQT like protein 3; Potassium voltage gated channel KQT like subfamily member 3; Potassium voltage gated channel subfamily KQT member 3; Potassium voltage-gated channel subfamily KQT member 3; Voltage gated potassium channel subunit Kv7.3; Voltage-gated potassium channel subunit Kv7.3;
抗原和靶标
- O43525 KCNQ3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43525 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y125 | Phosphorylation | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| Y502 | Phosphorylation | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| T579 | Phosphorylation | Uniprot | |
| T663 | Phosphorylation | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| T746 | Phosphorylation | Uniprot | |
| Y770 | Phosphorylation | Uniprot | |
| S771 | Phosphorylation | Uniprot | |
| S810 | Phosphorylation | Uniprot |
研究背景
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.
KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36.
Cell membrane>Multi-pass membrane protein.
Predominantly expressed in brain.
Heterotetramer with KCNQ2; form the heterotetrameric M potassium channel. Interacts with calmodulin; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel. Heteromultimer with KCNQ5. May associate with KCNE2. Interacts with IQCJ-SCHIP1 (By similarity).
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
研究领域
· Organismal Systems > Nervous system > Cholinergic synapse.
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