产品: SIK2 抗体
货号: AF6539
描述: Rabbit polyclonal antibody to SIK2
应用: ELISA(peptide)
反应: Human, Mouse, Rat
分子量: 104kD(Calculated).
蛋白号: Q9H0K1
RRID: AB_2847263

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产品描述

来源:
Rabbit
应用:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
SIK2 Antibody detects endogenous levels of total SIK2.
RRID:
AB_2847263
引用格式: Affinity Biosciences Cat# AF6539, RRID:AB_2847263.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DKFZp434K1115; EC 2.7.11.1; KIAA0781; LOH11CR1I; QIK; Qin induced kinase; Qin-induced kinase; Salt inducible kinase 2; Salt inducible protein kinase 2; Salt inducible serine/threonine kinase 2; Salt-inducible protein kinase 2; Serine/threonine protein kinase SIK2; Serine/threonine protein kinase SNF1 like kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK 2; SIK-2; SIK2; SIK2_HUMAN; SNF1 like kinase; SNF1 like kinase 2; SNF1LK2;

抗原和靶标

免疫原:

A synthesized peptide derived from human SIK2.

Uniprot:
基因/基因ID:
序列:
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN

翻译修饰 - Q9H0K1 作为底物

Site PTM Type Enzyme
T25 Phosphorylation
K28 Ubiquitination
K43 Ubiquitination
K49 Ubiquitination
K53 Acetylation
K53 Ubiquitination
K63 Ubiquitination
K81 Ubiquitination
S90 Phosphorylation
K144 Ubiquitination
K168 Sumoylation
T175 Phosphorylation Q15831 (STK11)
K266 Ubiquitination
K313 Ubiquitination
S342 Phosphorylation
S343 Phosphorylation
S358 Phosphorylation P31751 (AKT2) , P17612 (PRKACA)
T359 Phosphorylation
S379 Phosphorylation
T484 Phosphorylation
S486 Phosphorylation
S512 Phosphorylation
S534 Phosphorylation
K536 Ubiquitination
S545 Phosphorylation
R547 Methylation
S576 Phosphorylation
S587 Phosphorylation
T589 Phosphorylation
S590 Phosphorylation
K686 Ubiquitination
K692 Ubiquitination
Y700 Phosphorylation
K702 Ubiquitination

翻译修饰 - Q9H0K1 作为激酶

Substrate Site Source
P35568 (IRS1) S794 Uniprot
Q15078 (CDK5R1) S91 Uniprot
Q53ET0 (CRTC2) S171 Uniprot
Q9BV73 (CEP250) S2392 Uniprot
Q9BV73 (CEP250) S2394 Uniprot

研究背景

功能:

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

翻译修饰:

Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.

Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with and phosphorylates TORC2/CRTC2.

蛋白家族:

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

研究领域

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

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