| 产品: | PBK/TOPK 抗体 |
| 货号: | AF6556 |
| 描述: | Rabbit polyclonal antibody to PBK/TOPK |
| 应用: | WB |
| 反应: | Human, Mouse |
| 分子量: | 36kD(Calculated). |
| 蛋白号: | Q96KB5 |
| RRID: | AB_2847280 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6556, RRID:AB_2847280.
展开/折叠
Cancer/testis antigen 84; CT84; Epididymis luminal protein 164; FLJ14385; HEL164; Lymphokine activated killer T cell originated protein kinase; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK like protein kinase; MAPKK-like protein kinase; Nori 3; Nori-3; Nori3; PBK; PDZ binding kinase; PDZ-binding kinase; Serine/threonine protein kinase; Spermatogenesis related protein kinase; Spermatogenesis-related protein kinase; SPK; T LAK cell originated protein kinase; T-LAK cell-originated protein kinase; TOPK; TOPK_HUMAN;
抗原和靶标
A synthesized peptide derived from human PBK/TOPK.
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
- Q96KB5 TOPK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
翻译修饰 - Q96KB5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| K8 | Sumoylation | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| T9 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S11 | Phosphorylation | Uniprot | |
| K12 | Acetylation | Uniprot | |
| K12 | Sumoylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| K16 | Acetylation | Uniprot | |
| K17 | Acetylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| T24 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| K64 | Acetylation | Uniprot | |
| K64 | Sumoylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K65 | Sumoylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| Y74 | Phosphorylation | P12931 (SRC) | Uniprot |
| S76 | Phosphorylation | Uniprot | |
| Y78 | Phosphorylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| K87 | Acetylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| Y100 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K155 | Sumoylation | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K162 | Sumoylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K169 | Sumoylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| K176 | Sumoylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| T181 | Phosphorylation | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| Y272 | Phosphorylation | P12931 (SRC) | Uniprot |
| S310 | Phosphorylation | Uniprot |
翻译修饰 - Q96KB5 作为激酶
研究背景
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Phosphorylated; in a cell-cycle dependent manner at mitosis.
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
Interacts with DLG1 and TP53.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
限制条款
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