| 产品: | Kir6.2 抗体 |
| 货号: | AF6590 |
| 描述: | Rabbit polyclonal antibody to Kir6.2 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 分子量: | 44kD(Calculated). |
| 蛋白号: | Q14654 |
| RRID: | AB_2847314 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6590, RRID:AB_2847314.
展开/折叠
ATP sensitive inward rectifier potassium channel 11; Beta cell inward rectifier subunit; BIR; HHF 2; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; Inwardly rectifying potassium channel KIR6.2; IRK 11; IRK11; KCNJ11; Kir 6.2; Kir6.2; MGC133230; PHHI; Potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; Potassium inwardly rectifying channel J11; TNDM 3; TNDM3;
抗原和靶标
A synthesized peptide derived from human Kir6.2.
- Q14654 KCJ11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
翻译修饰 - Q14654 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T180 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S208 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Q9UQM7 (CAMK2A) , Q13557 (CAMK2D) | Uniprot |
| K332 | Ubiquitination | Uniprot | |
| T341 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S372 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | P28482 (MAPK1) | Uniprot |
研究背景
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.
Membrane>Multi-pass membrane protein.
Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2.
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Type II diabetes mellitus.
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
限制条款
产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.