| 产品: | CDKN2A/p16INK4a 抗体 |
| 货号: | AF6667 |
| 描述: | Rabbit polyclonal antibody to CDKN2A/p16INK4a |
| 应用: | ELISA(peptide) |
| 反应: | Human |
| 分子量: | 17kD(Calculated). |
| 蛋白号: | P42771 |
| RRID: | AB_2847390 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6667, RRID:AB_2847390.
展开/折叠
Cyclin-dependent kinase inhibitor 2A;Cyclin-dependent kinase 4 inhibitor A;CDK4I;Multiple tumor suppressor 1;MTS-1;p16-INK4a;p16-INK4;p16INK4A;CDKN2A;CDKN2;MTS1;
抗原和靶标
A synthesized peptide derived from human CDKN2A/p16INK4a.
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
- P42771 CDN2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD
翻译修饰 - P42771 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S7 | Phosphorylation | Q13535 (ATR) | Uniprot |
| S8 | Phosphorylation | O14920 (IKBKB) , Q13535 (ATR) | Uniprot |
| Y44 | Phosphorylation | Uniprot | |
| R99 | Methylation | Uniprot | |
| R131 | Methylation | Uniprot | |
| R138 | Methylation | Uniprot | |
| S140 | Phosphorylation | Q13535 (ATR) | Uniprot |
| S152 | Phosphorylation | Q13535 (ATR) | Uniprot |
研究背景
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Phosphorylation seems to increase interaction with CDK4.
Cytoplasm. Nucleus.
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Human Diseases > Cancers: Specific types > Pancreatic cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Glioma. (View pathway)
· Human Diseases > Cancers: Specific types > Melanoma. (View pathway)
· Human Diseases > Cancers: Specific types > Bladder cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Non-small cell lung cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
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