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| 产品: | Glycogen Synthase 抗体 |
| 货号: | AF6165 |
| 描述: | Rabbit polyclonal antibody to Glycogen Synthase |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 85,89kDa; 84kD(Calculated). |
| 蛋白号: | P13807 |
| RRID: | AB_2835031 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6165, RRID:AB_2835031.
展开/折叠
Glycogen [starch] synthase; Glycogen synthase 1 (muscle); Glycogen synthase 1; GSY; GYS; Gys1; GYS1_HUMAN; muscle;
抗原和靶标
- P13807 GYS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P13807 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| T6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| K88 | Acetylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K100 | Acetylation | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| T426 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| T485 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| Y604 | Phosphorylation | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| Y636 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | Q96RG2 (PASK) , P49841 (GSK3B) , P49840 (GSK3A) , Q92630 (DYRK2) | Uniprot |
| S645 | Phosphorylation | Q15759 (MAPK11) , P49841 (GSK3B) | Uniprot |
| S647 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| S653 | Phosphorylation | P49841 (GSK3B) , Q15759 (MAPK11) | Uniprot |
| S657 | Phosphorylation | Uniprot | |
| Y675 | Phosphorylation | Uniprot | |
| K683 | Ubiquitination | Uniprot | |
| S698 | Phosphorylation | Uniprot | |
| T700 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot | |
| T713 | Phosphorylation | Uniprot | |
| T715 | Phosphorylation | Uniprot | |
| S716 | Phosphorylation | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| T721 | Phosphorylation | Q15759 (MAPK11) | Uniprot |
| S723 | Phosphorylation | Uniprot | |
| S727 | Phosphorylation | Q15759 (MAPK11) | Uniprot |
| T729 | Phosphorylation | Uniprot | |
| S730 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot |
研究背景
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
Interacts with GYG1.
Belongs to the glycosyltransferase 3 family.
研究领域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
文献引用
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