| 产品: | CRYAB 抗体 |
| 货号: | AF6754 |
| 描述: | Rabbit polyclonal antibody to CRYAB |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 20kD; 20kD(Calculated). |
| 蛋白号: | P02511 |
| RRID: | AB_2847477 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6754, RRID:AB_2847477.
展开/折叠
AACRYA; Alpha B crystallin; Alpha crystallin B chain; Alpha(B)-crystallin; Alpha-crystallin B chain; CRYA2; Cryab; CRYAB_HUMAN; Crystallin alpha B; Crystallin alpha polypeptide 2; CTPP2; Heat shock 20 kD like protein; Heat shock protein beta 5; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY REN 27; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component;
抗原和靶标
A synthesized peptide derived from human CRYAB.
Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373).
- P02511 CRYAB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
翻译修饰 - P02511 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| R22 | Methylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| R50 | Methylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| R74 | Methylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| K90 | Acetylation | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K92 | Acetylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| T132 | Phosphorylation | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| K166 | Acetylation | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| T170 | O-Glycosylation | Uniprot |
研究背景
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Cytoplasm. Nucleus.
Note: Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373).
Lens as well as other tissues. Expressed in myocardial tissue.
Heteropolymer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages.
Belongs to the small heat shock protein (HSP20) family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
限制条款
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