(2)
| 产品: | TIMP2 抗体 |
| 货号: | AF0264 |
| 描述: | Rabbit polyclonal antibody to TIMP2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Horse |
| 分子量: | 24kDa; 24kD(Calculated). |
| 蛋白号: | P16035 |
| RRID: | AB_2833438 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0264, RRID:AB_2833438.
展开/折叠
CSC 21K; CSC-21K; CSC21K; Metalloproteinase inhibitor 2; Metalloproteinase inhibitor 2 precursor; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP-2; TIMP2; TIMP2_HUMAN; Tissue Inhibitor of Metalloproteinase 2; Tissue inhibitor of metalloproteinases 2;
抗原和靶标
- P16035 TIMP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P16035 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K53 | Ubiquitination | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| Y62 | Phosphorylation | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot |
研究背景
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
The activity of TIMP2 is dependent on the presence of disulfide bonds.
Secreted.
Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
Belongs to the protease inhibitor I35 (TIMP) family.
文献引用
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