| 产品: | Perilipin-1 抗体 |
| 货号: | AF6834 |
| 描述: | Rabbit polyclonal antibody to Perilipin-1 |
| 应用: | WB ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 56kD(Calculated). |
| 蛋白号: | O60240 |
| RRID: | AB_2847557 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6834, RRID:AB_2847557.
展开/折叠
Lipid droplet associated protein; Lipid droplet-associated protein; PERI; Perilipin A; Perilipin; Perilipin-1; PerilipinA; PLIN; PLIN1; PLIN1_HUMAN;
抗原和靶标
A synthesized peptide derived from human Perilipin-1.
Detected in adipocytes from white adipose tissue (at protein level) (PubMed:27832861). Detected in visceral adipose tissue and mammary gland (PubMed:9521880).
- O60240 PLIN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS
翻译修饰 - O60240 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T8 | Phosphorylation | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T85 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| T299 | Phosphorylation | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| Y401 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| T476 | Phosphorylation | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| Y515 | Phosphorylation | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Uniprot |
研究背景
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).
Endoplasmic reticulum. Lipid droplet.
Note: Lipid droplet surface-associated.
Detected in adipocytes from white adipose tissue (at protein level). Detected in visceral adipose tissue and mammary gland.
Interacts with ABHD5 (By similarity). Interacts with CIDEC. Interacts with AQP7.
Belongs to the perilipin family.
研究领域
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.
限制条款
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