| 产品: | PKA-R2 beta 抗体 |
| 货号: | AF6952 |
| 描述: | Rabbit polyclonal antibody to PKA-R2 beta |
| 应用: | ELISA(peptide) |
| 反应: | Human |
| 分子量: | 46kD(Calculated). |
| 蛋白号: | P31323 |
| RRID: | AB_2847742 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6952, RRID:AB_2847742.
展开/折叠
AI451071; AW061005; cAMP dependent protein kinase type II beta regulatory chain; cAMP dependent protein kinase type II beta regulatory subunit; cAMP-dependent protein kinase type II-beta regulatory subunit; H RG363E19.2; KAP3_HUMAN; MGC116401; Pkarb2; PRKAR 2; PRKAR2; PRKAR2B; Protein kinase cAMP dependent regulatory type II beta; RATDNA; RII beta; RII(beta); RIIbeta; WUGSC:H RG363E19.2;
抗原和靶标
A synthesized peptide derived from human PKA-R2 beta.
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
- P31323 KAP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
翻译修饰 - P31323 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T69 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| S114 | Phosphorylation | P31323 (PRKAR2B) , P17612 (PRKACA) | Uniprot |
| C116 | S-Nitrosylation | Uniprot | |
| Y120 | Phosphorylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| T357 | Phosphorylation | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| T417 | Phosphorylation | Uniprot |
翻译修饰 - P31323 作为激酶
研究背景
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Phosphorylated by the activated catalytic chain.
Cytoplasm. Cell membrane.
Note: Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2. Forms a complex composed of PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity.
Belongs to the cAMP-dependent kinase regulatory chain family.
研究领域
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
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