| 产品: | Claudin 6 抗体 |
| 货号: | AF6972 |
| 描述: | Rabbit polyclonal antibody to Claudin 6 |
| 应用: | IF/ICC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 23kD(Calculated). |
| 蛋白号: | P56747 |
| RRID: | AB_2847762 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6972, RRID:AB_2847762.
展开/折叠
Claudin-6; Claudin6; CLD6_HUMAN; CLDN 6; CLDN6; OTTHUMP00000159248; Skullin 2; Skullin; UNQ757/PRO1488;
抗原和靶标
A synthesized peptide derived from human Claudin 6.
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
- P56747 CLD6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV
翻译修饰 - P56747 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y200 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| T202 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| Y214 | Phosphorylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| Y219 | Phosphorylation | Uniprot |
研究背景
Plays a major role in tight junction-specific obliteration of the intercellular space.
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN.
Belongs to the claudin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
限制条款
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