| 产品: | PPM1D 抗体 |
| 货号: | DF13783 |
| 描述: | Rabbit polyclonal antibody to PPM1D |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse |
| 分子量: | 70kD; 67kD(Calculated). |
| 蛋白号: | O15297 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
EC 3.1.3.16; p53 induced protein phosphatase 1; p53-induced protein phosphatase 1; PP2C delta; PP2C-delta; PP2CD; Ppm1d; PPM1D_HUMAN; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent delta isoform; Protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium dependent 1 delta; Protein phosphatase magnesium-dependent 1 delta; Protein phosphatase Mg2+/Mn2+ dependent 1D; Protein phosphatase Wip1; Wild type p53 induced phosphatase 1; WIP 1; WIP1;
抗原和靶标
A synthesized peptide derived from Human PPM1D.
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
- O15297 PPM1D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
研究背景
Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
Nucleus. Cytoplasm>Cytosol.
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Interacts with CHEK1 and CHEK2; dephosphorylates them. Interacts with MAPK14.
Belongs to the PP2C family.
研究领域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
限制条款
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