产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CRB3; CRUM3_HUMAN; crumbs homolog 3 (Drosophila); Crumbs protein homolog 3; crumbs, Drosophila, homolog of, 3; PRO1158; protein crumbs homolog 3; UNQ588;
抗原和靶标
A synthesized peptide derived from Human CRB3.
Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
- Q9BUF7 CRUM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTEGTYRPSSEEQVGARVPPTPNLKLPPEERLI
研究背景
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.
Apical cell membrane>Single-pass type I membrane protein. Cell junction>Tight junction.
Note: Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
Interacts with MPP5, PARD6A and PATJ.
The PDZ-binding motif is involved in the interactions with PARD6A and MPP5.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
限制条款
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