产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
5''-cyclic phosphodiesterase subunit delta; GMP PDE delta; GMP-PDE delta; p17 protein; PDE 6; PDE 6D; PDE D; PDE6; PDE6D; PDE6D_HUMAN; PDED; Phosphodiesterase 6D cGMP specific; Phosphodiesterase 6D cGMP specific rod delta; Protein p17; Retinal rod photoreceptor cGMP phosphodiesterase delta; Retinal rod rhodopsin sensitive cGMP 3' 5' cyclic phosphodiesterase subunit delta; Retinal rod rhodopsin-sensitive cGMP 3'';
抗原和靶标
A synthesized peptide derived from Human PDE6 delta.
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
- O43924 PDE6D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
研究背景
Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
Cytoplasm>Cytosol. Cytoplasmic vesicle membrane>Peripheral membrane protein. Cytoplasm>Cytoskeleton>Cilium basal body.
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated Ras family members, including RAP2A and RAP2C (By similarity). Interacts with prenylated RHEB and NRAS. Interacts with prenylated HRAS and KRAS. Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes. Interacts with prenylated INPP5E. Interacts with RPGR. Interacts with ARL2. Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3. Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins.
Belongs to the PDE6D/unc-119 family.
研究领域
· Metabolism > Nucleotide metabolism > Purine metabolism.
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