产品: ACOT7 抗体
货号: DF14107
描述: Rabbit polyclonal antibody to ACOT7
应用: ELISA(peptide)
反应: Human, Mouse, Rat
分子量: 40kD; 42kD(Calculated).
蛋白号: O00154

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
ACOT7 Antibody detects endogenous levels of total ACOT7.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ACH1; ACOT 7; ACOT7; ACT; Acyl CoA thioesterase 7; Acyl CoA thioesterase long chain; Acyl-CoA thioesterase 7; BACH; BACH_HUMAN; Brain acyl CoA hydrolase; Brain acyl-CoA hydrolase; CTE-II; CTE-IIa; Cytosolic acyl coenzyme A thioester hydrolase; hBACH; LACH; LACH1; Long chain acyl-CoA thioester hydrolase;

抗原和靶标

免疫原:

A synthesized peptide derived from Human ACOT7.

Uniprot:
基因/基因ID:
表达:
O00154 BACH_HUMAN:

Isoform 4 is expressed exclusively in brain.

序列:
MKLLARALRLCEFGRQASSRRLVAGQGCVGPRRGCCAPVQVVGPRADLPPCGACITGRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP

研究背景

功能:

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.

细胞定位:

Cytoplasm>Cytosol.

Cytoplasm>Cytosol.

Mitochondrion.

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Isoform 4 is expressed exclusively in brain.

亚基结构:

Homohexamer.

蛋白家族:

Both HotDog ACOT-type hydrolase domains are required for efficient activity.

研究领域

· Metabolism > Lipid metabolism > Fatty acid elongation.

· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.

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