产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0276, RRID:AB_2833446.
展开/折叠
FKSG45; FLJ42398; MGC27076; Protease FKSG45; SENP5; SENP5_HUMAN; Sentrin specific protease SENP5; Sentrin-specific protease 5; Sentrin/SUMO specific protease SENP5; Sentrin/SUMO-specific protease SENP5; SUMO specific protease SENP5; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5;
抗原和靶标
- Q96HI0 SENP5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPVTWNRQLRHFQGRKKALQIQKTWIKDEPLCAKTKFNVATQNVSTLSSKVKRKDAKHFISSSKTLLRLQAEKLLSSAKNSDHEYCREKNLLKAVTDFPSNSALGQANGHRPRTDPQPSDFPMKFNGESQSPGESGTIVVTLNNHKRKGFCYGCCQGPEHHRNGGPLIPKKFQLNQHRRIKLSPLMMYEKLSMIRFRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQETRRENGEGGSCSPFPSPEPKDPSCRHQPYFPDMDSSAVVKGTNSHVPDCHTKGSSFLGKELSLDEAFPDQQNGSATNAWDQSSCSSPKWECTELIHDIPLPEHRSNTMFISETEREIMTLGQENQTSSVSDDRVKLSVSGADTSVSSVDGPVSQKAVQNENSYQMEEDGSLKQSILSSELLDHPYCKSPLEAPLVCSGLKLENQVGGGKNSQKASPVDDEQLSVCLSGFLDEVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLMD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96HI0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Acetylation | Uniprot | |
| K6 | Acetylation | Uniprot | |
| K11 | Acetylation | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| Y243 | Phosphorylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| K449 | Ubiquitination | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| K486 | Ubiquitination | Uniprot | |
| K513 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| K530 | Ubiquitination | Uniprot | |
| T651 | Phosphorylation | Uniprot | |
| Y679 | Phosphorylation | Uniprot | |
| T682 | Phosphorylation | Uniprot | |
| K687 | Ubiquitination | Uniprot | |
| K746 | Ubiquitination | Uniprot |
研究背景
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Nucleus>Nucleolus.
Interacts with CCAR2.
Belongs to the peptidase C48 family.
限制条款
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