产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
DKFZP566I133; ectopic P-granules autophagy protein 3 homolog; NF E2 induceble protein 2; NF E2 inducible protein 2; ni 2; protein ni 2; Tango5; TDC1; TMEM49; Transmembrane protein 49; transport and golgi organization 5 homolog; Vacuole membrane protein 1; vmp1; VMP1_HUMAN;
抗原和靶标
A synthesized peptide derived from Human TMEM49.
- Q96GC9 VMP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQRLNSEEKTK
研究背景
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Required for autophagosome formation.
Endoplasmic reticulum-Golgi intermediate compartment membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein. Vacuole membrane>Multi-pass membrane protein. Endoplasmic reticulum.
Interacts with BECN1 (By similarity). Interacts with TJP1. Interacts with TP53INP2. Interacts with TMEM41B.
The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
Belongs to the VMP1 family.
研究领域
· Cellular Processes > Transport and catabolism > Autophagy - animal. (View pathway)
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