产品: Uroplakin III 抗体
货号: DF14425
描述: Rabbit polyclonal antibody to Uroplakin III
应用: WB IHC IF/ICC
反应: Human, Mouse
分子量: 31kD(Calculated).
蛋白号: O75631

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
Uroplakin III Antibody detects endogenous levels of total Uroplakin III.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

MGC119178; OTTHUMP00000028951; UP III; UP3a; UPIII; UPIIIA; UPK 3; UPK 3A; UPK3; UPK3A; UPK3A_HUMAN; Uroplakin 3A; Uroplakin III; Uroplakin-3a; Uroplakin3A; UroplakinIII;

抗原和靶标

免疫原:

A synthesized peptide derived from Human Uroplakin III.

Uniprot:
基因/基因ID:
表达:
O75631 UPK3A_HUMAN:

Expressed in ureter.

序列:
MPPLWALLALGCLRFGSAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD

研究背景

功能:

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

细胞定位:

Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in ureter.

亚基结构:

Heterodimer with uroplakin-1B (UPK1B).

蛋白家族:

Belongs to the uroplakin-3 family.

研究领域

· Human Diseases > Cancers: Specific types > Bladder cancer.   (View pathway)

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