VSIG4 Antibody - #DF14591

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产品: VSIG4 抗体
货号: DF14591
描述: Rabbit polyclonal antibody to VSIG4
应用: WB IHC IF/ICC
反应: Human, Rat
分子量: 40/50kD; 44kD(Calculated).
蛋白号: Q9Y279

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
克隆:
Polyclonal
特异性:
VSIG4 Antibody detects endogenous levels of VSIG4.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; Protein Z39Ig; UNQ317/PRO362; V set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; VSIG4_HUMAN; Z39IG;

抗原和靶标

免疫原:

A synthesized peptide derived from human VSIG4.

Uniprot:

Q9Y279(VSIG4_HUMAN) >>Visit HPA database.

基因/基因ID:
VSIG4(11326)
表达:
Q9Y279 VSIG4_HUMAN:

Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.

序列:
MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC

研究背景

功能:

Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

细胞定位:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.

研究领域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction. Frontiers in immunology, 2023 (PubMed: 38169731) [IF=7.3]

Application: IHC    Species: Human    Sample:

Figure 12 Validation of the prognostic model using the H-score obtained by immunohistochemistry (IHC). (A) Osteosarcoma patients were categorized into low and high-risk groups based on the immunohistochemistry (IHC) results of PLEKHO2, VSIG4, MPP1, and GBP2. (B) The high-risk group exhibited a poorer survival outcome compared to the low-risk group. (C) Time-dependent ROC curves were generated in the IHC validation cohort, with AUC values of 0.800 at 1 year, 0.722 at 3 years, and 0.654 at 5 years. (D, E) The distribution of risk scores, the survival status of each patient, and a heatmap depicting the prognostic 4-gene signature were analyzed in the IHC validation cohort.

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