RAMP3 Antibody - #DF14693

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产品: RAMP3 抗体
货号: DF14693
描述: Rabbit polyclonal antibody to RAMP3
应用: IF/ICC
反应: Human, Mouse, Rat
分子量: 17kD(Calculated).
蛋白号: O60896

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
RAMP3 Antibody detects endogenous levels of RAMP3.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Calcitonin receptor like receptor activity modifying protein 3; CRLR activity modifying protein 3; CRLR activity-modifying protein 3; OTTHUMP00000159549; OTTHUMP00000214279; OTTHUMP00000214280; Receptor (calcitonin) activity modifying protein 3; Receptor (G protein-coupled) activity modifying protein 3; Receptor activity modifying protein 3;

抗原和靶标

免疫原:

A synthesized peptide derived from human RAMP3.

Uniprot:

O60896(RAMP3_HUMAN) >>Visit HPA database.

基因/基因ID:
RAMP3(10268)
表达:
O60896 RAMP3_HUMAN:

Strongly expressed in lung, breast, immune system and fetal tissues.

序列:
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

研究背景

功能:

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

细胞定位:

Cell membrane>Single-pass type I membrane protein. Membrane>Single-pass type I membrane protein.
Note: Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Strongly expressed in lung, breast, immune system and fetal tissues.

亚基结构:

Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

蛋白家族:

Belongs to the RAMP family.

研究领域

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

文献引用

1). Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. ACTA DIABETOLOGICA, 2022 (PubMed: 34978596) [IF=3.8]

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