JCHAIN Antibody - #DF14810

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产品: JCHAIN 抗体
货号: DF14810
描述: Rabbit polyclonal antibody to JCHAIN
应用: IHC IF/ICC
反应: Human, Mouse
分子量: 18kD(Calculated).
蛋白号: P01591

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
JCHAIN Antibody detects endogenous levels of JCHAIN.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

IGCJ; IGJ_HUMAN; Immunoglobulin J chain; Immunoglobulin J polypeptide linker protein for immunoglobulin alpha and mu polypeptides; immunoglobulin joining chain; JCH; JCHAIN; Joining chain of multimeric IgA and IgM;

抗原和靶标

免疫原:

A synthesized peptide derived from human JCHAIN.

Uniprot:

P01591(IGJ_HUMAN) >>Visit HPA database.

基因/基因ID:
JCHAIN(3512)
序列:
MKNHLLFWGVLAVFIKAVHVKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD

研究背景

功能:

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location

文献引用

1). Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification. International journal of oral science, 2024 (PubMed: 38622125) [IF=14.9]

Application: IHC    Species: Human    Sample:

Fig. 6 Unveiling a four-gene risk model for prognostication in HNSCC patients. a Comparative boxplot delineating the modeling-related gene expression levels within the two groups. b Forest plot mapping out OS-related clinical factors via single-factor Cox regression analysis. c Kaplan–Meier survival plots manifesting prognosis-linked risk scores’ impact. d ROC curve spectra, a predictive gauge for 1, 3, 5, and 10-year OS dynamics. e Comparative analysis spotlighting differential gene expressions between high and low-risk groups. f Kaplan-Meier survival curves of HNSCC patients based on four genes Risk-scores. Representative IHC staining images (g) and IHC score (h) in the two groups. Scale bar, 100 μm

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