产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
FUN14 domain containing 1; FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN; fundc1;
抗原和靶标
A synthesized peptide derived from human FUNDC1.
- Q8IVP5 FUND1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS
翻译修饰 - Q8IVP5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y11 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| Y18 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot |
研究背景
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.
Mitochondrion outer membrane>Multi-pass membrane protein.
Widely expressed.
Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
Belongs to the FUN14 family.
限制条款
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