CLEC4M Antibody - #DF15512

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产品: CLEC4M 抗体
货号: DF15512
描述: Rabbit polyclonal antibody to CLEC4M
应用: IHC IF/ICC
反应: Human
分子量: 45kD(Calculated).
蛋白号: Q9H2X3

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
CLEC4M Antibody detects endogenous levels of CLEC4M.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C type lectin domain family 4, member M; C-type lectin domain family 4 member M; CD209 antigen like; CD209 antigen like protein 1; CD209 antigen-like protein 1; CD209L; CD209L1; CD299; CD299 antigen; CLC4M_HUMAN; CLEC4M; DC SIGN related protein; DC SIGN2; DC SIGNR; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; DCSIGN related protein; DCSIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; L SIGN; L-SIGN; Liver/lymph node specific ICAM3 grabbing nonintegrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; Mannose binding C type lectin DC SIGNR; MGC129964; MGC47866;

抗原和靶标

免疫原:

A synthesized peptide derived from human CLEC4M.

Uniprot:

Q9H2X3(CLC4M_HUMAN) >>Visit HPA database.

基因/基因ID:
CLEC4M(10332)
表达:
Q9H2X3 CLC4M_HUMAN:

Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.

序列:
MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE

研究背景

功能:

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

(Microbial infection) Acts as an attachment receptor for Ebolavirus.

(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.

(Microbial infection) Acts as an attachment receptor for HIV-1.

(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.

(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.

(Microbial infection) Acts as an attachment receptor for Influenzavirus.

(Microbial infection) Acts as an attachment receptor for SARS coronavirus.

(Microbial infection) Acts as an attachment receptor for West-nile virus.

(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.

(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.

(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

细胞定位:

Cell membrane>Single-pass type II membrane protein.

Cell membrane>Single-pass type II membrane protein.

Cell membrane>Single-pass type II membrane protein.

Secreted.

Secreted.

Secreted.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.

亚基结构:

Homotetramer.

(Microbial infection) Interacts with ebola virus glycoprotein.

(Microbial infection) Interacts with hepatitis C virus E1 and E2 protein.

(Microbial infection) Interacts with HIV-1 gp120.

(Microbial infection) Interacts with human coronavirus 229E spike glycoprotein.

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 gB protein.

(Microbial infection) Interacts with influenzavirus hemagglutinin.

(Microbial infection) Interacts with SARS coronavirus spike glycoprotein.

(Microbial infection) Interacts with west-nile virus envelope protein E.

(Microbial infection) Interacts with Japanese encephalitis virus E protein.

(Microbial infection) Interacts with Marburg virus glycoprotein.

(Microbial infection) Interacts with M.bovis LprG.

蛋白家族:

The tandem repeat domain, also called neck domain, mediates oligomerization.

研究领域

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Human Diseases > Infectious diseases: Viral > Measles.

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