| 产品: | XPF 抗体 |
| 货号: | AF0295 |
| 描述: | Rabbit polyclonal antibody to XPF |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 103kDa; 104kD(Calculated). |
| 蛋白号: | Q92889 |
| RRID: | AB_2833461 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0295, RRID:AB_2833461.
展开/折叠
DNA excision repair protein ERCC 4; DNA excision repair protein ERCC-4; DNA excision repair protein ERCC4; DNA repair endonuclease XPF; DNA repair protein complementing XP F cells; DNA repair protein complementing XP-F cells; ERCC 11; ERCC 4; ERCC11; ERCC4; Excision repair complementing defective in Chinese hamster; Excision repair cross complementing rodent repair deficiency complementation group 4; excision repair cross-complementation group 4; FANCQ; RAD 1; RAD1; Xeroderma pigmentosum complementation group F; Xeroderma pigmentosum group F complementing protein; Xeroderma pigmentosum group F-complementing protein; Xeroderma pigmentosum VI; XP, group G; XP6; XPF_HUMAN;
抗原和靶标
- Q92889 XPF_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESGQPARRIAMAPLLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEITSNSRYEVYTQGGVIFATSRILVVDFLTDRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEKISEKMEIKEGEETKKELVLESNPKWEALTEVLKEIEAENKESEALGGPGQVLICASDDRTCSQLRDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERASTKERTLKKKKRKLTLTQMVGKPEELEEEGDVEEGYRREISSSPESCPEEIKHEEFDVNLSSDAAFGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRGALFQEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDFIHTSFAEVVSKGKGKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92889 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y191 | Phosphorylation | Uniprot | |
| K260 | Acetylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| K289 | Acetylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| T493 | Phosphorylation | Uniprot | |
| K500 | Acetylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| K632 | Ubiquitination | Uniprot | |
| T660 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| T669 | Phosphorylation | Uniprot | |
| T710 | Phosphorylation | Uniprot | |
| Y742 | Phosphorylation | Uniprot | |
| Y752 | Phosphorylation | Uniprot | |
| K753 | Ubiquitination | Uniprot | |
| K843 | Ubiquitination | Uniprot | |
| K861 | Ubiquitination | Uniprot |
研究背景
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Nucleus.
Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-XPF/ERCC1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.
Belongs to the XPF family.
研究领域
· Genetic Information Processing > Replication and repair > Nucleotide excision repair.
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
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