产品: ATRIP 抗体
货号: AF6468
描述: Rabbit polyclonal antibody to ATRIP
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog, Chicken
分子量: 80kDa; 86kD(Calculated).
蛋白号: Q8WXE1
RRID: AB_2835287

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(89%), Dog(100%), Chicken(89%)
克隆:
Polyclonal
特异性:
ATRIP Antibody detects endogenous levels of total ATRIP.
RRID:
AB_2835287
引用格式: Affinity Biosciences Cat# AF6468, RRID:AB_2835287.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AGS1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; DKFZp762J2115; FLJ12343; MGC20625; MGC21482; MGC26740;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q8WXE1 ATRIP_HUMAN:

Ubiquitous.

描述:
ATRIP is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
序列:
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDLEELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Chicken
89
Rabbit
89
Horse
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q8WXE1 作为底物

Site PTM Type Enzyme
S9 Phosphorylation
S13 Phosphorylation
T26 Phosphorylation
S31 Phosphorylation
K32 Acetylation
S38 Phosphorylation
S68 Phosphorylation Q13535 (ATR)
S72 Phosphorylation Q13535 (ATR)
K96 Ubiquitination
K122 Ubiquitination
S162 Phosphorylation
K205 Ubiquitination
K214 Ubiquitination
S219 Phosphorylation
S221 Phosphorylation
S224 Phosphorylation P24941 (CDK2)
S239 Phosphorylation P24941 (CDK2)
K270 Ubiquitination
K295 Ubiquitination
S305 Phosphorylation
T307 Phosphorylation
S310 Phosphorylation
S512 Phosphorylation
S518 Phosphorylation
T523 Phosphorylation
Y636 Phosphorylation

研究背景

功能:

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

翻译修饰:

Phosphorylated by ATR.

细胞定位:

Nucleus.
Note: Redistributes to discrete nuclear foci upon DNA damage.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous.

亚基结构:

Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.

蛋白家族:

The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.

Belongs to the ATRIP family.

研究领域

· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.

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