LRRC3B Antibody - #DF16048

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产品: LRRC3B 抗体
货号: DF16048
描述: Rabbit polyclonal antibody to LRRC3B
应用: WB IHC
反应: Human, Mouse
分子量: 29kD(Calculated).
蛋白号: Q96PB8

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
LRRC3B Antibody detects endogenous levels of LRRC3B.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Leucine rich repeat containing 3B; Leucine-rich repeat protein LRP15; Leucine-rich repeat-containing protein 3B; LRC3B_HUMAN; LRRC3B; MGC102927;

抗原和靶标

免疫原:

A synthesized peptide derived from human LRRC3B.

Uniprot:

Q96PB8(LRC3B_HUMAN) >>Visit HPA database.

基因/基因ID:
LRRC3B(116135)
序列:
MNLVDLWLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDISTVV

研究背景

细胞定位:

Membrane>Single-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the LRRC3 family.

文献引用

1). LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy. Frontiers in Immunology, 2023 (PubMed: 36798137) [IF=7.3]

Application: WB    Species: Human    Sample: B2B and Hs578T cell

Figure 2 LRRC3B variants, localization, and expression profile under physiological conditions. (A) The LRRC3B protein topology revealed extracellular membrane localization with PTMs. (B) The LRRC3B-associated disease network. (C) Boxplots showing differential LRRC3B expression levels (log CPM+1) between tumor and adjacent normal tissues across the TCGA database. (D) Real-time RT-PCR analysis of LRRC3B mRNA in H1299 and Hs578T cell lines. (E) Protein levels of LRRC3B in B2B and H1299 cell lines assessed by immunoblot. (F) Protein levels of LRRC3B in B2B and Hs578T cell lines assessed by immunoblot. LRRC3B: leucine rich repeat containing 3B; PTMs: protein post-translational modifications; TCGA: The Cancer Genome Atlas.

Application: IF/ICC    Species: Human    Sample: lung cancer tissues

Figure 5 Multiplex IHC images of lung cancer tissues with immune cell biomarkers and LRRC3B expression. mIHC: multiplex immunofluorescence staining; LRRC3B: leucine rich repeat containing 3B.

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