产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CD34; CD34 antigen; CD34 molecule; CD34_HUMAN; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; Mucosialin; OTTHUMP00000034733; OTTHUMP00000034734;
抗原和靶标
A synthesized peptide derived from human CD34.
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
- P28906 CD34_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL
翻译修饰 - P28906 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S198 | Phosphorylation | Uniprot | |
| K268 | Acetylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| Y329 | Phosphorylation | Uniprot | |
| Y330 | Phosphorylation | Uniprot | |
| T331 | Phosphorylation | Uniprot | |
| Y339 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | P31751 (AKT2) | Uniprot |
| S354 | Phosphorylation | Uniprot |
研究背景
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Highly glycosylated.
Phosphorylated on serine residues by PKC.
Membrane>Single-pass type I membrane protein.
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Belongs to the CD34 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
限制条款
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