产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Activator protein 1; AP 1; AP1; Jun B; Jun B proto oncogene; Jun B protooncogene; Junb; JunB proto oncogene; JunB protoncogene 9; JunB protooncogene; JUNB_HUMAN; Transcription factor jun B; Transcription factor jun-B; Transcription factor junB;
抗原和靶标
A synthesized peptide derived from human JUNB(Accession P17275)
- P17275 JUNB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGPEGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPPVYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
翻译修饰 - P17275 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Sumoylation | Uniprot | |
| K33 | Sumoylation | Uniprot | |
| K36 | Acetylation | Uniprot | |
| K36 | Sumoylation | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K51 | Sumoylation | Uniprot | |
| Y68 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| T102 | Phosphorylation | Q16539 (MAPK14) , P45983 (MAPK8) | Uniprot |
| T104 | Phosphorylation | Q16539 (MAPK14) , P45983 (MAPK8) | Uniprot |
| Y109 | Phosphorylation | Uniprot | |
| Y111 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| T153 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y182 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y188 | Phosphorylation | P00519 (ABL1) | Uniprot |
| S189 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| T238 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K240 | Sumoylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| S251 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| T255 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| S259 | Phosphorylation | Uniprot | |
| K304 | Sumoylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| T330 | Phosphorylation | Uniprot |
研究背景
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Ubiquitinated by ITCH, leading to its degradation.
Nucleus.
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).
Belongs to the bZIP family. Jun subfamily.
研究领域
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
限制条款
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