产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Channel associated protein of synapse 110; Channel associated protein of synapses 110kD; Channel-associated protein of synapse-110; Chapsyn 110; Chapsyn-110; Chapsyn110; Discs, large homolog 2 (Drosophila); Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; Dlg 2; dlg2; DLG2_HUMAN; Dlgh 2; Dlgh2; FLJ37266; Gm1197; MGC131811; Postsynaptic density protein PSD 93; Postsynaptic density protein PSD-93; Postsynaptic density protein PSD93; PSD 93; PSD93;
抗原和靶标
A synthesized peptide derived from human PSD93, corresponding to a region within the N-terminal amino acids.
- Q15700 DLG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
翻译修饰 - Q15700 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S28 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y327 | Phosphorylation | Uniprot | |
| Y340 | Phosphorylation | Uniprot | |
| Y348 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S530 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| Y719 | Phosphorylation | Uniprot | |
| Y726 | Phosphorylation | Uniprot |
研究背景
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
Cell membrane>Lipid-anchor. Cell junction>Synapse>Postsynaptic density. Cell junction>Synapse. Membrane. Cell projection>Axon. Perikaryon.
Note: Concentrated in soma and postsynaptic density of a subset of neurons.
Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity).
An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
Belongs to the MAGUK family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
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