产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Antigen identified by monoclonal antibody Ki 67; Antigen identified by monoclonal antibody Ki-67; Antigen KI-67; Antigen KI67; Antigen Ki67; KI67_HUMAN; KIA; Marker of proliferation Ki-67; MIB 1; MIB; MKI67; PPP1R105; Proliferation marker protein Ki-67; Proliferation related Ki 67 antigen; Protein phosphatase 1 regulatory subunit 105; RP11-380J17.2;
抗原和靶标
A synthesized peptide derived from human Ki67, corresponding to a region within the internal amino acids.
- P46013 KI67_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWPTRRLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDVITIIDRSFRYENESLQNGRKSTEFPRKIREQEPARRVSRSSFSSDPDEKAQDSKAYSKITEGKVSGNPQVHIKNVKEDSTADDSKDSVAQGTTNVHSSEHAGRNGRNAADPISGDFKEISSVKLVSRYGELKSVPTTQCLDNSKKNESPFWKLYESVKKELDVKSQKENVLQYCRKSGLQTDYATEKESADGLQGETQLLVSRKSRPKSGGSGHAVAEPASPEQELDQNKGKGRDVESVQTPSKAVGASFPLYEPAKMKTPVQYSQQQNSPQKHKNKDLYTTGRRESVNLGKSEGFKAGDKTLTPRKLSTRNRTPAKVEDAADSATKPENLSSKTRGSIPTDVEVLPTETEIHNEPFLTLWLTQVERKIQKDSLSKPEKLGTTAGQMCSGLPGLSSVDINNFGDSINESEGIPLKRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRKSLVMHTPPVLKKIIKEQPQPSGKQESGSEIHVEVKAQSLVISPPAPSPRKTPVASDQRRRSCKTAPASSSKSQTEVPKRGGRKSGNLPSKRVSISRSQHDILQMICSKRRSGASEANLIVAKSWADVVKLGAKQTQTKVIKHGPQRSMNKRQRRPATPKKPVGEVHSQFSTGHANSPCTIIIGKAHTEKVHVPARPYRVLNNFISNQKMDFKEDLSGIAEMFKTPVKEQPQLTSTCHIAISNSENLLGKQFQGTDSGEEPLLPTSESFGGNVFFSAQNAAKQPSDKCSASPPLRRQCIRENGNVAKTPRNTYKMTSLETKTSDTETEPSKTVSTANRSGRSTEFRNIQKLPVESKSEETNTEIVECILKRGQKATLLQQRREGEMKEIERPFETYKENIELKENDEKMKAMKRSRTWGQKCAPMSDLTDLKSLPDTELMKDTARGQNLLQTQDHAKAPKSEKGKITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREPAGDGKSIRTFKESPKQILDPAARVTGMKKWPRTPKEEAQSLEDLAGFKELFQTPGPSEESMTDEKTTKIACKSPPPESVDTPTSTKQWPKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDLAGTLPGSKRQLQTPKEKAQALEDLAGFKELFQTPGHTEELVAAGKTTKIPCDSPQSDPVDTPTSTKQRPKRSIRKADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKLDLTENLTGSKRRPQTPKEEAQALEDLTGFKELFQTPGHTEEAVAAGKTTKMPCESSPPESADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPGGEDKSINAFRETAKQKLDPAASVTGSKRHPKTKEKAQPLEDLAGLKELFQTPVCTDKPTTHEKTTKIACRSQPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIYAFMGTPVQKLDLTENLTGSKRRLQTPKEKAQALEDLAGFKELFQTRGHTEESMTNDKTAKVACKSSQPDPDKNPASSKRRLKTSLGKVGVKEELLAVGKLTQTSGETTHTHTEPTGDGKSMKAFMESPKQILDSAASLTGSKRQLRTPKGKSEVPEDLAGFIELFQTPSHTKESMTNEKTTKVSYRASQPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHTPKPAVGEEKDINTFLGTPVQKLDQPGNLPGSNRRLQTRKEKAQALEELTGFRELFQTPCTDNPTTDEKTTKKILCKSPQSDPADTPTNTKQRPKRSLKKADVEEEFLAFRKLTPSAGKAMHTPKAAVGEEKDINTFVGTPVEKLDLLGNLPGSKRRPQTPKEKAKALEDLAGFKELFQTPGHTEESMTDDKITEVSCKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVGKLTQTSGKTTQTHRETAGDGKSIKAFKESAKQMLDPANYGTGMERWPRTPKEEAQSLEDLAGFKELFQTPDHTEESTTDDKTTKIACKSPPPESMDTPTSTRRRPKTPLGKRDIVEELSALKQLTQTTHTDKVPGDEDKGINVFRETAKQKLDPAASVTGSKRQPRTPKGKAQPLEDLAGLKELFQTPICTDKPTTHEKTTKIACRSPQPDPVGTPTIFKPQSKRSLRKADVEEESLALRKRTPSVGKAMDTPKPAGGDEKDMKAFMGTPVQKLDLPGNLPGSKRWPQTPKEKAQALEDLAGFKELFQTPGTDKPTTDEKTTKIACKSPQPDPVDTPASTKQRPKRNLRKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNINTFVETPVQKLDLLGNLPGSKRQPQTPKEKAEALEDLVGFKELFQTPGHTEESMTDDKITEVSCKSPQPESFKTSRSSKQRLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSKSIKAFKESPKQILDPAASVTGSRRQLRTRKEKARALEDLVDFKELFSAPGHTEESMTIDKNTKIPCKSPPPELTDTATSTKRCPKTRPRKEVKEELSAVERLTQTSGQSTHTHKEPASGDEGIKVLKQRAKKKPNPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQESLTAGKATKIPCESPPLEVVDTTASTKRHLRTRVQKVQVKEEPSAVKFTQTSGETTDADKEPAGEDKGIKALKESAKQTPAPAASVTGSRRRPRAPRESAQAIEDLAGFKDPAAGHTEESMTDDKTTKIPCKSSPELEDTATSSKRRPRTRAQKVEVKEELLAVGKLTQTSGETTHTDKEPVGEGKGTKAFKQPAKRKLDAEDVIGSRRQPRAPKEKAQPLEDLASFQELSQTPGHTEELANGAADSFTSAPKQTPDSGKPLKISRRVLRAPKVEPVGDVVSTRDPVKSQSKSNTSLPPLPFKRGGGKDGSVTGTKRLRCMPAPEEIVEELPASKKQRVAPRARGKSSEPVVIMKRSLRTSAKRIEPAEELNSNDMKTNKEEHKLQDSVPENKGISLRSRRQNKTEAEQQITEVFVLAERIEINRNEKKPMKTSPEMDIQNPDDGARKPIPRDKVTENKRCLRSARQNESSQPKVAEESGGQKSAKVLMQNQKGKGEAGNSDSMCLRSRKTKSQPAASTLESKSVQRVTRSVKRCAENPKKAEDNVCVKKIRTRSHRDSEDI
翻译修饰 - P46013 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K11 | Ubiquitination | Uniprot | |
K46 | Ubiquitination | Uniprot | |
K83 | Ubiquitination | Uniprot | |
R93 | Methylation | Uniprot | |
K107 | Ubiquitination | Uniprot | |
S108 | Phosphorylation | Uniprot | |
T109 | Phosphorylation | Uniprot | |
K114 | Ubiquitination | Uniprot | |
S125 | Phosphorylation | Uniprot | |
S127 | Phosphorylation | Uniprot | |
S128 | Phosphorylation | Uniprot | |
S130 | Phosphorylation | Uniprot | |
S131 | Phosphorylation | Uniprot | |
K136 | Ubiquitination | Uniprot | |
K145 | Ubiquitination | Uniprot | |
K150 | Ubiquitination | Uniprot | |
K160 | Ubiquitination | Uniprot | |
K163 | Sumoylation | Uniprot | |
K163 | Ubiquitination | Uniprot | |
K172 | Ubiquitination | Uniprot | |
S184 | Phosphorylation | Uniprot | |
S185 | Phosphorylation | Uniprot | |
K204 | Sumoylation | Uniprot | |
K204 | Ubiquitination | Uniprot | |
K210 | Ubiquitination | Uniprot | |
K219 | Methylation | Uniprot | |
K219 | Ubiquitination | Uniprot | |
K231 | Ubiquitination | Uniprot | |
K232 | Ubiquitination | Uniprot | |
S235 | Phosphorylation | Uniprot | |
K239 | Ubiquitination | Uniprot | |
Y241 | Phosphorylation | Uniprot | |
S243 | Phosphorylation | Uniprot | |
K245 | Sumoylation | Uniprot | |
K245 | Ubiquitination | Uniprot | |
K251 | Ubiquitination | Uniprot | |
K254 | Ubiquitination | Uniprot | |
K263 | Ubiquitination | Uniprot | |
S264 | Phosphorylation | Uniprot | |
T268 | Phosphorylation | Uniprot | |
K274 | Ubiquitination | Uniprot | |
S296 | Phosphorylation | Uniprot | |
S299 | Phosphorylation | Uniprot | |
S308 | Phosphorylation | Uniprot | |
K317 | Ubiquitination | Uniprot | |
S325 | Phosphorylation | Uniprot | |
T328 | Phosphorylation | Uniprot | |
S330 | Phosphorylation | Uniprot | |
K331 | Ubiquitination | Uniprot | |
S336 | Phosphorylation | Uniprot | |
Y340 | Phosphorylation | Uniprot | |
K344 | Ubiquitination | Uniprot | |
K346 | Ubiquitination | Uniprot | |
T347 | Phosphorylation | Uniprot | |
S352 | Phosphorylation | Uniprot | |
S357 | Phosphorylation | P24941 (CDK2) | Uniprot |
K360 | Ubiquitination | Uniprot | |
K364 | Ubiquitination | Uniprot | |
Y367 | Phosphorylation | Uniprot | |
T368 | Phosphorylation | Uniprot | |
S374 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
K379 | Acetylation | Uniprot | |
K379 | Ubiquitination | Uniprot | |
K388 | Acetylation | Uniprot | |
T389 | Phosphorylation | Uniprot | |
T391 | Phosphorylation | Uniprot | |
S396 | Phosphorylation | Uniprot | |
T401 | Phosphorylation | Uniprot | |
S411 | Phosphorylation | Uniprot | |
T413 | Phosphorylation | Uniprot | |
K414 | Ubiquitination | Uniprot | |
K421 | Ubiquitination | Uniprot | |
S425 | Phosphorylation | Uniprot | |
K458 | Ubiquitination | Uniprot | |
S460 | Phosphorylation | Uniprot | |
K466 | Acetylation | Uniprot | |
K502 | Methylation | Uniprot | |
K502 | Ubiquitination | Uniprot | |
S507 | Phosphorylation | Uniprot | |
T525 | Phosphorylation | Uniprot | |
K528 | Ubiquitination | Uniprot | |
K537 | Ubiquitination | Uniprot | |
S538 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
T543 | Phosphorylation | Uniprot | |
K548 | Ubiquitination | Uniprot | |
K552 | Sumoylation | Uniprot | |
K552 | Ubiquitination | Uniprot | |
K560 | Ubiquitination | Uniprot | |
S563 | Phosphorylation | Uniprot | |
S565 | Phosphorylation | Uniprot | |
S575 | Phosphorylation | Uniprot | |
S579 | Phosphorylation | Uniprot | |
S584 | Phosphorylation | Uniprot | |
K587 | Sumoylation | Uniprot | |
K587 | Ubiquitination | Uniprot | |
T588 | Phosphorylation | Uniprot | |
S592 | Phosphorylation | Uniprot | |
S598 | Phosphorylation | Uniprot | |
T601 | Phosphorylation | Uniprot | |
S605 | Phosphorylation | Uniprot | |
K608 | Ubiquitination | Uniprot | |
T611 | Phosphorylation | Uniprot | |
K615 | Ubiquitination | Uniprot | |
K620 | Ubiquitination | Uniprot | |
S621 | Phosphorylation | Uniprot | |
K627 | Ubiquitination | Uniprot | |
S634 | Phosphorylation | Uniprot | |
K645 | Ubiquitination | Uniprot | |
S648 | Phosphorylation | Uniprot | |
S651 | Phosphorylation | Uniprot | |
K659 | Ubiquitination | Uniprot | |
S660 | Phosphorylation | Uniprot | |
K666 | Ubiquitination | Uniprot | |
K670 | Ubiquitination | Uniprot | |
K675 | Ubiquitination | Uniprot | |
T694 | Phosphorylation | Uniprot | |
K696 | Ubiquitination | Uniprot | |
K697 | Ubiquitination | Uniprot | |
S704 | Phosphorylation | Uniprot | |
S707 | Phosphorylation | Uniprot | |
S713 | Phosphorylation | Uniprot | |
T716 | Phosphorylation | Uniprot | |
K721 | Ubiquitination | Uniprot | |
K726 | Ubiquitination | Uniprot | |
K745 | Sumoylation | Uniprot | |
K745 | Ubiquitination | Uniprot | |
K749 | Sumoylation | Uniprot | |
K749 | Ubiquitination | Uniprot | |
S753 | Phosphorylation | Uniprot | |
K760 | Ubiquitination | Uniprot | |
T761 | Phosphorylation | P06493 (CDK1) | Uniprot |
K764 | Ubiquitination | Uniprot | |
K818 | Ubiquitination | Uniprot | |
S825 | Phosphorylation | Uniprot | |
S827 | Phosphorylation | Uniprot | |
T844 | Phosphorylation | Uniprot | |
Y849 | Phosphorylation | Uniprot | |
K850 | Ubiquitination | Uniprot | |
S853 | Phosphorylation | Uniprot | |
K857 | Ubiquitination | Uniprot | |
T858 | Phosphorylation | Uniprot | |
S859 | Phosphorylation | Uniprot | |
K867 | Ubiquitination | Uniprot | |
S878 | Phosphorylation | Uniprot | |
K886 | Ubiquitination | Uniprot | |
K892 | Sumoylation | Uniprot | |
K892 | Ubiquitination | Uniprot | |
K906 | Ubiquitination | Uniprot | |
K910 | Ubiquitination | Uniprot | |
K923 | Ubiquitination | Uniprot | |
K933 | Ubiquitination | Uniprot | |
K957 | Ubiquitination | Uniprot | |
K968 | Ubiquitination | Uniprot | |
S969 | Phosphorylation | Uniprot | |
K977 | Ubiquitination | Uniprot | |
T988 | Phosphorylation | Uniprot | |
K993 | Ubiquitination | Uniprot | |
K1004 | Ubiquitination | Uniprot | |
T1017 | Phosphorylation | Uniprot | |
K1022 | Ubiquitination | Uniprot | |
K1026 | Ubiquitination | Uniprot | |
S1028 | Phosphorylation | Uniprot | |
K1031 | Ubiquitination | Uniprot | |
K1035 | Sumoylation | Uniprot | |
K1035 | Ubiquitination | Uniprot | |
K1043 | Ubiquitination | Uniprot | |
K1063 | Acetylation | Uniprot | |
K1063 | Ubiquitination | Uniprot | |
T1067 | Phosphorylation | Uniprot | |
K1069 | Sumoylation | Uniprot | |
S1071 | Phosphorylation | Uniprot | |
K1073 | Ubiquitination | Uniprot | |
T1091 | Phosphorylation | Uniprot | |
K1093 | Sumoylation | Uniprot | |
K1093 | Ubiquitination | Uniprot | |
S1098 | Phosphorylation | Uniprot | |
K1106 | Ubiquitination | Uniprot | |
T1111 | Phosphorylation | Uniprot | |
S1115 | Phosphorylation | Uniprot | |
S1118 | Phosphorylation | Uniprot | |
S1131 | Phosphorylation | Uniprot | |
S1136 | Phosphorylation | Uniprot | |
T1139 | Phosphorylation | Uniprot | |
T1141 | Phosphorylation | Uniprot | |
S1142 | Phosphorylation | Uniprot | |
T1143 | Phosphorylation | Uniprot | |
K1144 | Ubiquitination | Uniprot | |
K1153 | Sumoylation | Uniprot | |
K1153 | Ubiquitination | Uniprot | |
K1165 | Acetylation | Uniprot | |
K1165 | Ubiquitination | Uniprot | |
T1167 | Phosphorylation | Uniprot | |
S1169 | Phosphorylation | Uniprot | |
K1172 | Ubiquitination | Uniprot | |
T1176 | Phosphorylation | Uniprot | |
K1178 | Acetylation | Uniprot | |
K1185 | Acetylation | Uniprot | |
K1188 | Sumoylation | Uniprot | |
K1188 | Ubiquitination | Uniprot | |
T1193 | Phosphorylation | Uniprot | |
K1197 | Ubiquitination | Uniprot | |
T1203 | Phosphorylation | Uniprot | |
S1207 | Phosphorylation | Uniprot | |
K1208 | Acetylation | Uniprot | |
K1208 | Ubiquitination | Uniprot | |
T1213 | Phosphorylation | Uniprot | |
K1217 | Ubiquitination | Uniprot | |
K1228 | Ubiquitination | Uniprot | |
T1233 | Phosphorylation | Uniprot | |
T1237 | Phosphorylation | Uniprot | |
K1245 | Ubiquitination | Uniprot | |
K1248 | Ubiquitination | Uniprot | |
C1251 | S-Nitrosylation | Uniprot | |
S1253 | Phosphorylation | Uniprot | |
S1256 | Phosphorylation | Uniprot | |
T1261 | Phosphorylation | Uniprot | |
T1263 | Phosphorylation | Uniprot | |
S1264 | Phosphorylation | Uniprot | |
T1265 | Phosphorylation | Uniprot | |
K1266 | Ubiquitination | Uniprot | |
S1272 | Phosphorylation | Uniprot | |
K1275 | Ubiquitination | Uniprot | |
S1291 | Phosphorylation | Uniprot | |
T1298 | Phosphorylation | Uniprot | |
S1302 | Phosphorylation | Uniprot | |
T1315 | Phosphorylation | Uniprot | |
T1323 | Phosphorylation | Uniprot | |
T1327 | Phosphorylation | Uniprot | |
S1329 | Phosphorylation | Uniprot | |
K1330 | Acetylation | Uniprot | |
K1330 | Ubiquitination | Uniprot | |
T1335 | Phosphorylation | Uniprot | |
K1337 | Ubiquitination | Uniprot | |
T1347 | Phosphorylation | Uniprot | |
K1350 | Ubiquitination | Uniprot | |
T1355 | Phosphorylation | Uniprot | |
T1359 | Phosphorylation | Uniprot | |
K1367 | Ubiquitination | Uniprot | |
S1375 | Phosphorylation | Uniprot | |
S1376 | Phosphorylation | Uniprot | |
S1380 | Phosphorylation | Uniprot | |
T1383 | Phosphorylation | Uniprot | |
T1385 | Phosphorylation | Uniprot | |
S1386 | Phosphorylation | Uniprot | |
T1387 | Phosphorylation | Uniprot | |
T1393 | Phosphorylation | Uniprot | |
K1402 | Ubiquitination | Uniprot | |
S1405 | Phosphorylation | Uniprot | |
K1408 | Acetylation | Uniprot | |
K1409 | Ubiquitination | Uniprot | |
T1411 | Phosphorylation | Uniprot | |
S1414 | Phosphorylation | Uniprot | |
K1422 | Ubiquitination | Uniprot | |
K1441 | Ubiquitination | Uniprot | |
S1447 | Phosphorylation | Uniprot | |
T1449 | Phosphorylation | Uniprot | |
S1451 | Phosphorylation | Uniprot | |
K1452 | Acetylation | Uniprot | |
K1452 | Ubiquitination | Uniprot | |
K1460 | Ubiquitination | Uniprot | |
K1471 | Ubiquitination | Uniprot | |
T1476 | Phosphorylation | Uniprot | |
T1480 | Phosphorylation | Uniprot | |
K1482 | Acetylation | Uniprot | |
K1482 | Ubiquitination | Uniprot | |
T1485 | Phosphorylation | Uniprot | |
S1496 | Phosphorylation | Uniprot | |
T1503 | Phosphorylation | Uniprot | |
T1505 | Phosphorylation | Uniprot | |
S1506 | Phosphorylation | Uniprot | |
S1507 | Phosphorylation | Uniprot | |
K1508 | Ubiquitination | Uniprot | |
S1511 | Phosphorylation | Uniprot | |
K1512 | Methylation | Uniprot | |
K1512 | Ubiquitination | Uniprot | |
S1514 | Phosphorylation | Uniprot | |
K1517 | Sumoylation | Uniprot | |
K1517 | Ubiquitination | Uniprot | |
T1531 | Phosphorylation | Uniprot | |
S1533 | Phosphorylation | Uniprot | |
T1540 | Phosphorylation | Uniprot | |
K1542 | Ubiquitination | Uniprot | |
S1546 | Phosphorylation | Uniprot | |
K1549 | Ubiquitination | Uniprot | |
Y1552 | Phosphorylation | Uniprot | |
T1557 | Phosphorylation | Uniprot | |
T1565 | Phosphorylation | Uniprot | |
T1569 | Phosphorylation | Uniprot | |
S1571 | Phosphorylation | Uniprot | |
K1572 | Acetylation | Uniprot | |
K1572 | Ubiquitination | Uniprot | |
T1577 | Phosphorylation | Uniprot | |
K1581 | Acetylation | Uniprot | |
K1581 | Ubiquitination | Uniprot | |
K1592 | Acetylation | Uniprot | |
K1592 | Ubiquitination | Uniprot | |
T1597 | Phosphorylation | Uniprot | |
T1601 | Phosphorylation | Uniprot | |
S1604 | Phosphorylation | Uniprot | |
K1612 | Acetylation | Uniprot | |
S1618 | Phosphorylation | Uniprot | |
S1628 | Phosphorylation | Uniprot | |
S1629 | Phosphorylation | Uniprot | |
S1636 | Phosphorylation | Uniprot | |
K1639 | Acetylation | Uniprot | |
K1639 | Ubiquitination | Uniprot | |
K1643 | Sumoylation | Uniprot | |
K1643 | Ubiquitination | Uniprot | |
K1651 | Ubiquitination | Uniprot | |
S1656 | Phosphorylation | Uniprot | |
T1660 | Phosphorylation | Uniprot | |
S1679 | Phosphorylation | Uniprot | |
S1686 | Phosphorylation | Uniprot | |
S1689 | Phosphorylation | Uniprot | |
T1691 | Phosphorylation | Uniprot | |
S1693 | Phosphorylation | Uniprot | |
K1694 | Ubiquitination | Uniprot | |
T1699 | Phosphorylation | Uniprot | |
K1703 | Sumoylation | Uniprot | |
K1703 | Ubiquitination | Uniprot | |
S1704 | Phosphorylation | Uniprot | |
T1719 | Phosphorylation | Uniprot | |
S1721 | Phosphorylation | Uniprot | |
K1724 | Ubiquitination | Uniprot | |
S1726 | Phosphorylation | Uniprot | |
K1734 | Ubiquitination | Uniprot | |
S1736 | Phosphorylation | Uniprot | |
Y1737 | Phosphorylation | Uniprot | |
S1740 | Phosphorylation | Uniprot | |
T1747 | Phosphorylation | Uniprot | |
T1749 | Phosphorylation | Uniprot | |
S1750 | Phosphorylation | Uniprot | |
S1751 | Phosphorylation | Uniprot | |
K1752 | Ubiquitination | Uniprot | |
S1758 | Phosphorylation | Uniprot | |
K1761 | Ubiquitination | Uniprot | |
T1764 | Phosphorylation | O14757 (CHEK1) | Uniprot |
T1775 | Phosphorylation | Uniprot | |
S1777 | Phosphorylation | Uniprot | |
T1784 | Phosphorylation | Uniprot | |
K1793 | Ubiquitination | Uniprot | |
T1797 | Phosphorylation | Uniprot | |
T1801 | Phosphorylation | Uniprot | |
K1805 | Ubiquitination | Uniprot | |
S1815 | Phosphorylation | Uniprot | |
K1825 | Ubiquitination | Uniprot | |
T1841 | Phosphorylation | Uniprot | |
T1844 | Phosphorylation | Uniprot | |
T1848 | Phosphorylation | Uniprot | |
T1849 | Phosphorylation | Uniprot | |
K1852 | Ubiquitination | Uniprot | |
T1853 | Phosphorylation | Uniprot | |
K1860 | Methylation | Uniprot | |
K1860 | Ubiquitination | Uniprot | |
S1861 | Phosphorylation | Uniprot | |
S1864 | Phosphorylation | Uniprot | |
T1869 | Phosphorylation | Uniprot | |
T1871 | Phosphorylation | Uniprot | |
K1874 | Ubiquitination | Uniprot | |
S1880 | Phosphorylation | Uniprot | |
K1883 | Sumoylation | Uniprot | |
K1883 | Ubiquitination | Uniprot | |
K1895 | Ubiquitination | Uniprot | |
T1897 | Phosphorylation | Uniprot | |
S1899 | Phosphorylation | Uniprot | |
K1902 | Acetylation | Uniprot | |
K1902 | Ubiquitination | Uniprot | |
T1906 | Phosphorylation | Uniprot | |
K1915 | Ubiquitination | Uniprot | |
T1919 | Phosphorylation | Uniprot | |
T1923 | Phosphorylation | Uniprot | |
K1927 | Ubiquitination | Uniprot | |
S1937 | Phosphorylation | Uniprot | |
K1938 | Acetylation | Uniprot | |
K1938 | Ubiquitination | Uniprot | |
T1943 | Phosphorylation | P06493 (CDK1) | Uniprot |
K1949 | Ubiquitination | Uniprot | |
K1958 | Ubiquitination | Uniprot | |
T1963 | Phosphorylation | Uniprot | |
T1967 | Phosphorylation | Uniprot | |
S1970 | Phosphorylation | Uniprot | |
S1980 | Phosphorylation | Uniprot | |
K1982 | Ubiquitination | Uniprot | |
S1983 | Phosphorylation | Uniprot | |
T1991 | Phosphorylation | Uniprot | |
S2002 | Phosphorylation | Uniprot | |
K2005 | Acetylation | Uniprot | |
K2005 | Ubiquitination | Uniprot | |
K2009 | Sumoylation | Uniprot | |
K2009 | Ubiquitination | Uniprot | |
T2019 | Phosphorylation | Uniprot | |
T2021 | Phosphorylation | Uniprot | |
T2025 | Phosphorylation | Uniprot | |
T2026 | Phosphorylation | Uniprot | |
T2028 | Phosphorylation | Uniprot | |
T2065 | Phosphorylation | Uniprot | |
K2067 | Sumoylation | Uniprot | |
K2067 | Ubiquitination | Uniprot | |
S2072 | Phosphorylation | Uniprot | |
K2080 | Ubiquitination | Uniprot | |
T2085 | Phosphorylation | Uniprot | |
T2089 | Phosphorylation | Uniprot | |
S2105 | Phosphorylation | Uniprot | |
S2110 | Phosphorylation | Uniprot | |
T2113 | Phosphorylation | Uniprot | |
T2115 | Phosphorylation | Uniprot | |
S2116 | Phosphorylation | Uniprot | |
T2123 | Phosphorylation | Uniprot | |
S2135 | Phosphorylation | Uniprot | |
K2138 | Ubiquitination | Uniprot | |
K2167 | Ubiquitination | Uniprot | |
S2173 | Phosphorylation | Uniprot | |
T2175 | Phosphorylation | Uniprot | |
K2178 | Acetylation | Uniprot | |
K2178 | Ubiquitination | Uniprot | |
K2187 | Ubiquitination | Uniprot | |
K2198 | Ubiquitination | Uniprot | |
T2203 | Phosphorylation | Uniprot | |
T2207 | Phosphorylation | Uniprot | |
T2211 | Phosphorylation | Uniprot | |
T2212 | Phosphorylation | Uniprot | |
T2217 | Phosphorylation | Uniprot | |
S2223 | Phosphorylation | Uniprot | |
T2231 | Phosphorylation | Uniprot | |
T2233 | Phosphorylation | Uniprot | |
K2236 | Ubiquitination | Uniprot | |
S2239 | Phosphorylation | Uniprot | |
K2240 | Methylation | Uniprot | |
S2242 | Phosphorylation | Uniprot | |
K2245 | Ubiquitination | Uniprot | |
S2252 | Phosphorylation | Uniprot | |
T2259 | Phosphorylation | Uniprot | |
S2261 | Phosphorylation | Uniprot | |
K2264 | Acetylation | Uniprot | |
T2268 | Phosphorylation | Uniprot | |
K2280 | Acetylation | Uniprot | |
K2280 | Sumoylation | Uniprot | |
T2285 | Phosphorylation | Uniprot | |
K2289 | Acetylation | Uniprot | |
K2289 | Ubiquitination | Uniprot | |
S2299 | Phosphorylation | Uniprot | |
K2300 | Acetylation | Uniprot | |
K2300 | Ubiquitination | Uniprot | |
T2305 | Phosphorylation | Uniprot | |
K2309 | Ubiquitination | Uniprot | |
K2320 | Ubiquitination | Uniprot | |
T2325 | Phosphorylation | Uniprot | |
T2328 | Phosphorylation | Uniprot | |
K2330 | Ubiquitination | Uniprot | |
T2332 | Phosphorylation | Uniprot | |
T2333 | Phosphorylation | Uniprot | |
T2337 | Phosphorylation | Uniprot | |
K2343 | Methylation | Uniprot | |
K2343 | Ubiquitination | Uniprot | |
S2344 | Phosphorylation | Uniprot | |
T2352 | Phosphorylation | Uniprot | |
S2355 | Phosphorylation | Uniprot | |
T2356 | Phosphorylation | Uniprot | |
K2366 | Sumoylation | Uniprot | |
K2366 | Ubiquitination | Uniprot | |
T2380 | Phosphorylation | Uniprot | |
S2382 | Phosphorylation | Uniprot | |
T2389 | Phosphorylation | Uniprot | |
S2395 | Phosphorylation | Uniprot | |
K2398 | Sumoylation | Uniprot | |
K2398 | Ubiquitination | Uniprot | |
T2402 | Phosphorylation | Uniprot | |
T2406 | Phosphorylation | Uniprot | |
K2410 | Ubiquitination | Uniprot | |
S2420 | Phosphorylation | Uniprot | |
K2421 | Acetylation | Uniprot | |
K2421 | Ubiquitination | Uniprot | |
T2426 | Phosphorylation | Uniprot | |
K2430 | Sumoylation | Uniprot | |
K2430 | Ubiquitination | Uniprot | |
K2441 | Ubiquitination | Uniprot | |
T2446 | Phosphorylation | Uniprot | |
T2450 | Phosphorylation | Uniprot | |
S2453 | Phosphorylation | Uniprot | |
T2455 | Phosphorylation | Uniprot | |
T2460 | Phosphorylation | Uniprot | |
S2463 | Phosphorylation | Uniprot | |
S2466 | Phosphorylation | Uniprot | |
S2471 | Phosphorylation | Uniprot | |
K2473 | Methylation | Uniprot | |
K2488 | Ubiquitination | Uniprot | |
K2492 | Sumoylation | Uniprot | |
K2500 | Ubiquitination | Uniprot | |
T2502 | Phosphorylation | Uniprot | |
T2504 | Phosphorylation | Uniprot | |
S2505 | Phosphorylation | Uniprot | |
T2508 | Phosphorylation | Uniprot | |
T2509 | Phosphorylation | Uniprot | |
T2516 | Phosphorylation | Uniprot | |
K2520 | Acetylation | Uniprot | |
K2523 | Acetylation | Uniprot | |
S2528 | Phosphorylation | Uniprot | |
K2530 | Ubiquitination | Uniprot | |
S2538 | Phosphorylation | Uniprot | |
S2542 | Phosphorylation | Uniprot | |
K2587 | Ubiquitination | Uniprot | |
S2588 | Phosphorylation | Uniprot | |
T2594 | Phosphorylation | Uniprot | |
T2598 | Phosphorylation | Uniprot | |
T2600 | Phosphorylation | Uniprot | |
K2601 | Ubiquitination | Uniprot | |
K2613 | Sumoylation | Uniprot | |
K2613 | Ubiquitination | Uniprot | |
K2634 | Ubiquitination | Uniprot | |
S2638 | Phosphorylation | Uniprot | |
T2683 | Phosphorylation | Uniprot | |
T2692 | Phosphorylation | Uniprot | |
S2695 | Phosphorylation | Uniprot | |
T2697 | Phosphorylation | Uniprot | |
S2708 | Phosphorylation | Uniprot | |
T2716 | Phosphorylation | Uniprot | |
T2717 | Phosphorylation | Uniprot | |
S2719 | Phosphorylation | Uniprot | |
T2720 | Phosphorylation | Uniprot | |
K2734 | Sumoylation | Uniprot | |
T2749 | Phosphorylation | Uniprot | |
T2750 | Phosphorylation | Uniprot | |
K2767 | Ubiquitination | Uniprot | |
S2769 | Phosphorylation | Uniprot | |
T2773 | Phosphorylation | Uniprot | |
T2781 | Phosphorylation | Uniprot | |
S2783 | Phosphorylation | Uniprot | |
S2793 | Phosphorylation | Uniprot | |
S2814 | Phosphorylation | Uniprot | |
T2816 | Phosphorylation | Uniprot | |
S2827 | Phosphorylation | Uniprot | |
S2828 | Phosphorylation | Uniprot | |
T2834 | Phosphorylation | Uniprot | |
T2836 | Phosphorylation | Uniprot | |
S2837 | Phosphorylation | Uniprot | |
S2838 | Phosphorylation | Uniprot | |
K2852 | Sumoylation | Uniprot | |
K2852 | Ubiquitination | Uniprot | |
T2862 | Phosphorylation | Uniprot | |
K2892 | Ubiquitination | Uniprot | |
S2901 | Phosphorylation | Uniprot | |
S2920 | Phosphorylation | Uniprot | |
S2925 | Phosphorylation | Uniprot | |
T2927 | Phosphorylation | Uniprot | |
T2931 | Phosphorylation | Uniprot | |
S2941 | Phosphorylation | Uniprot | |
T2949 | Phosphorylation | Uniprot | |
S2952 | Phosphorylation | Uniprot | |
K2967 | Ubiquitination | Uniprot | |
K2986 | Acetylation | Uniprot | |
K2997 | Acetylation | Uniprot | |
K2997 | Methylation | Uniprot | |
T3007 | Phosphorylation | Uniprot | |
T3009 | Phosphorylation | Uniprot | |
S3041 | Phosphorylation | Uniprot | |
S3042 | Phosphorylation | Uniprot | |
S3067 | Phosphorylation | Uniprot | |
S3082 | Phosphorylation | Uniprot | |
K3087 | Ubiquitination | Uniprot | |
T3127 | Phosphorylation | Uniprot | |
S3128 | Phosphorylation | Uniprot | |
K3180 | Ubiquitination | Uniprot | |
S3197 | Phosphorylation | Uniprot | |
T3213 | Phosphorylation | Uniprot | |
S3216 | Phosphorylation | Uniprot | |
K3217 | Ubiquitination | Uniprot | |
S3218 | Phosphorylation | Uniprot | |
T3223 | Phosphorylation | Uniprot | |
S3249 | Phosphorylation | Uniprot | |
S3253 | Phosphorylation | Uniprot |
研究背景
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Phosphorylated. Hyperphosphorylated in mitosis. Hyperphosphorylated form does not bind DNA.
Chromosome. Nucleus. Nucleus>Nucleolus.
Note: Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106).
Interacts with KIF15. Interacts (via the FHA domain) with NIFK. Interacts with PPP1CC. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.
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