产品: | HMGA2 抗体 |
货号: | AF4069 |
描述: | Rabbit polyclonal antibody to HMGA2 |
应用: | WB IF/ICC |
反应: | Human, Mouse |
预测: | Pig, Bovine, Sheep |
分子量: | 18kd; 12kD(Calculated). |
蛋白号: | P52926 |
RRID: | AB_2835351 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4069, RRID:AB_2835351.
展开/折叠
HMGA 2; BABL; High mobility group (nonhistone chromosomal) protein isoform I C; High mobility group (nonhistone chromosomal) protein isoform IC; High Mobility Group AT hook 2; High Mobility Group AT hook protein 2; High mobility group AT-hook protein 2; High mobility group protein HMGI C; High mobility group protein HMGI-C; High mobility group protein HMGIC; High mobility group protein I, isoform C; HMGA2; HMGA2_HUMAN; HMGI C; HMGIC; LIPO; Non histone chromosomal architectural protein HMGI C; Non histone chromosomal architectural protein HMGIC; Pygmy; STQTL9;
抗原和靶标
- P52926 HMGA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P52926 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S2 | Acetylation | Uniprot | |
S2 | Phosphorylation | Uniprot | |
R4 | Methylation | Uniprot | |
S12 | Phosphorylation | Uniprot | |
T13 | Phosphorylation | Uniprot | |
S14 | Phosphorylation | Uniprot | |
K26 | Acetylation | Uniprot | |
K26 | Methylation | Uniprot | |
K26 | Ubiquitination | Uniprot | |
T40 | Phosphorylation | Uniprot | |
S44 | Phosphorylation | P06493 (CDK1) | Uniprot |
S59 | Phosphorylation | P06493 (CDK1) | Uniprot |
T97 | Phosphorylation | Uniprot | |
T100 | Phosphorylation | Uniprot | |
S101 | Phosphorylation | Uniprot | |
S102 | Phosphorylation | Uniprot | |
S105 | Phosphorylation | Uniprot |
研究背景
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity).
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2 (By similarity).
Nucleus.
Interacts with E4F1. Interacts with NEK2 (By similarity).
Belongs to the HMGA family.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
文献引用
Application: WB Species: Human Sample: MDA-MB-453, MDA-MB-231 and MCF-10A cells
Application: WB Species: human Sample: SiHa and HeLa cells
限制条款
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