CDX2 Antibody - #AF4089

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产品: CDX2 抗体
货号: AF4089
描述: Rabbit polyclonal antibody to CDX2
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog, Chicken
分子量: 40kd; 34kD(Calculated).
蛋白号: Q99626
RRID: AB_2835355

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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相关下载
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Sheep(86%), Rabbit(100%), Dog(86%), Chicken(100%)
克隆:
Polyclonal
特异性:
CDX2 Antibody detects endogenous levels of total CDX2.
RRID:
AB_2835355
引用格式: Affinity Biosciences Cat# AF4089, RRID:AB_2835355.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Caudal type homeo box 2; Caudal type homeo box transcription factor 2; Caudal type homeobox 2; Caudal type homeobox protein 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX 2; CDX 3; CDX-3; Cdx2; CDX2/AS; CDX2_HUMAN; CDX3; Homeobox protein CDX 2; Homeobox protein CDX-2;

抗原和靶标

免疫原:
Uniprot:

Q99626(CDX2_HUMAN) >>Visit HPA database.

基因/基因ID:
CDX2(1045)
描述:
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
序列:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVTQ

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Chicken
100
Rabbit
100
Sheep
86
Dog
86
Horse
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q99626 作为底物

Site PTM Type Enzyme
S4 Phosphorylation
S60 Phosphorylation
S176 Phosphorylation
S226 Phosphorylation
S277 Phosphorylation
S283 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14) , P49841 (GSK3B)
S287 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14)
S291 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14)
S295 Phosphorylation Q16539 (MAPK14)
T310 Phosphorylation
T312 Phosphorylation

研究背景

功能:

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.

翻译修饰:

Phosphorylation of Ser-60 mediates the transactivation capacity.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the Caudal homeobox family.

研究领域

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

文献引用

1). Moderate Treadmill Exercise Modulates Gut Microbiota and Improves Intestinal Barrier in High-Fat-Diet-Induced Obese Mice via the AMPK/CDX2 Signaling Pathway. Diabetes Metabolic Syndrome and Obesity-Target & Therapy, 2022 (PubMed: 35087282) [IF=3.3]

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