产品: | ATM 抗体 |
货号: | AF4119 |
描述: | Rabbit polyclonal antibody to ATM |
应用: | WB IF/ICC |
反应: | Human, Mouse, Rat, Monkey |
预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
分子量: | 351kDa; 351kD(Calculated). |
蛋白号: | Q13315 |
RRID: | AB_2835361 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4119, RRID:AB_2835361.
展开/折叠
A-T mutated; A-T mutated homolog; AT mutated; AT1; ATA; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated gene; Ataxia telangiectasia mutated homolog (human); Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM serine/threonine kinase; ATM_HUMAN; DKFZp781A0353; MGC74674; OTTHUMP00000232981; Serine protein kinase ATM; Serine-protein kinase ATM; Serine/threonine-protein kinase ATM; Tefu; TEL1; TEL1, telomere maintenance 1, homolog; TELO1; Telomere fusion protein;
抗原和靶标
Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
- Q13315 ATM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13315 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S2 | Acetylation | Uniprot | |
S2 | Phosphorylation | Uniprot | |
T39 | Phosphorylation | Uniprot | |
K41 | Ubiquitination | Uniprot | |
S47 | Phosphorylation | Uniprot | |
S49 | Phosphorylation | Uniprot | |
K53 | Ubiquitination | Uniprot | |
Y54 | Phosphorylation | Uniprot | |
K66 | Ubiquitination | Uniprot | |
K70 | Ubiquitination | Uniprot | |
T72 | Phosphorylation | Uniprot | |
K79 | Ubiquitination | Uniprot | |
S83 | Phosphorylation | Uniprot | |
S85 | Phosphorylation | Uniprot | |
T86 | Phosphorylation | Uniprot | |
K106 | Ubiquitination | Uniprot | |
K116 | Ubiquitination | Uniprot | |
K147 | Ubiquitination | Uniprot | |
K177 | Ubiquitination | Uniprot | |
K196 | Ubiquitination | Uniprot | |
S200 | Phosphorylation | Uniprot | |
T202 | Phosphorylation | Uniprot | |
K208 | Ubiquitination | Uniprot | |
S214 | Phosphorylation | Uniprot | |
K215 | Ubiquitination | Uniprot | |
T237 | Phosphorylation | Uniprot | |
T297 | Phosphorylation | Uniprot | |
Y303 | Phosphorylation | Uniprot | |
S305 | Phosphorylation | Uniprot | |
K307 | Ubiquitination | Uniprot | |
S310 | Phosphorylation | Uniprot | |
Y313 | Phosphorylation | Uniprot | |
K331 | Ubiquitination | Uniprot | |
Y332 | Phosphorylation | Uniprot | |
S367 | Phosphorylation | Q13315 (ATM) | Uniprot |
Y370 | Phosphorylation | P00533 (EGFR) | Uniprot |
T372 | Phosphorylation | Uniprot | |
T373 | Phosphorylation | Uniprot | |
Y380 | Phosphorylation | Uniprot | |
S381 | Phosphorylation | Uniprot | |
K385 | Ubiquitination | Uniprot | |
K397 | Ubiquitination | Uniprot | |
S440 | Phosphorylation | Q13315 (ATM) , Q13535 (ATR) | Uniprot |
K468 | Ubiquitination | Uniprot | |
K477 | Ubiquitination | Uniprot | |
S569 | Phosphorylation | Uniprot | |
K573 | Ubiquitination | Uniprot | |
S644 | Phosphorylation | Uniprot | |
S646 | Phosphorylation | Uniprot | |
K673 | Ubiquitination | Uniprot | |
K748 | Ubiquitination | Uniprot | |
K750 | Ubiquitination | Uniprot | |
K764 | Ubiquitination | Uniprot | |
S794 | Phosphorylation | Q00535 (CDK5) | Uniprot |
S800 | Phosphorylation | Uniprot | |
S809 | Phosphorylation | Uniprot | |
K810 | Ubiquitination | Uniprot | |
K820 | Ubiquitination | Uniprot | |
S821 | Phosphorylation | Uniprot | |
K926 | Ubiquitination | Uniprot | |
T935 | Phosphorylation | Uniprot | |
Y980 | Phosphorylation | Uniprot | |
K988 | Ubiquitination | Uniprot | |
K1057 | Ubiquitination | Uniprot | |
K1101 | Ubiquitination | Uniprot | |
S1104 | Phosphorylation | Uniprot | |
K1109 | Ubiquitination | Uniprot | |
K1114 | Ubiquitination | Uniprot | |
K1126 | Methylation | Uniprot | |
K1126 | Ubiquitination | Uniprot | |
K1181 | Ubiquitination | Uniprot | |
K1196 | Ubiquitination | Uniprot | |
K1269 | Ubiquitination | Uniprot | |
K1280 | Ubiquitination | Uniprot | |
K1317 | Ubiquitination | Uniprot | |
K1323 | Ubiquitination | Uniprot | |
K1398 | Ubiquitination | Uniprot | |
S1403 | Phosphorylation | PR:Q96GD4 (hAURKB) , Q96GD4 (AURKB) | Uniprot |
K1410 | Ubiquitination | Uniprot | |
K1572 | Ubiquitination | Uniprot | |
K1580 | Ubiquitination | Uniprot | |
K1615 | Ubiquitination | Uniprot | |
K1625 | Ubiquitination | Uniprot | |
S1655 | Phosphorylation | Uniprot | |
K1656 | Methylation | Uniprot | |
K1656 | Ubiquitination | Uniprot | |
T1662 | Phosphorylation | Uniprot | |
K1665 | Ubiquitination | Uniprot | |
S1673 | Phosphorylation | Uniprot | |
K1692 | Ubiquitination | Uniprot | |
K1698 | Ubiquitination | Uniprot | |
K1701 | Ubiquitination | Uniprot | |
Y1717 | Phosphorylation | Uniprot | |
K1738 | Ubiquitination | Uniprot | |
K1744 | Ubiquitination | Uniprot | |
Y1753 | Phosphorylation | Uniprot | |
Y1763 | Phosphorylation | Uniprot | |
K1773 | Ubiquitination | Uniprot | |
K1782 | Ubiquitination | Uniprot | |
K1828 | Ubiquitination | Uniprot | |
S1878 | Phosphorylation | Uniprot | |
S1883 | Phosphorylation | Uniprot | |
T1885 | Phosphorylation | Q13315 (ATM) | Uniprot |
S1891 | Phosphorylation | Uniprot | |
S1893 | Phosphorylation | Q13315 (ATM) | Uniprot |
T1908 | Phosphorylation | Uniprot | |
Y1915 | Phosphorylation | Uniprot | |
S1974 | Phosphorylation | Uniprot | |
S1981 | Phosphorylation | PR:Q96GD4 (hAURKB) , Q13535 (ATR) , Q13315 (ATM) | Uniprot |
S1983 | Phosphorylation | Uniprot | |
T1985 | Phosphorylation | Uniprot | |
S1987 | Phosphorylation | Q13315 (ATM) | Uniprot |
S1988 | Phosphorylation | Uniprot | |
K1992 | Ubiquitination | Uniprot | |
S1993 | Phosphorylation | Uniprot | |
K1994 | Ubiquitination | Uniprot | |
T1997 | Phosphorylation | Uniprot | |
Y2019 | Phosphorylation | Uniprot | |
K2025 | Ubiquitination | Uniprot | |
T2031 | Phosphorylation | Uniprot | |
K2089 | Ubiquitination | Uniprot | |
K2148 | Ubiquitination | Uniprot | |
K2153 | Ubiquitination | Uniprot | |
K2160 | Ubiquitination | Uniprot | |
S2162 | Phosphorylation | Uniprot | |
S2165 | Phosphorylation | Uniprot | |
S2168 | Phosphorylation | Uniprot | |
Y2170 | Phosphorylation | Uniprot | |
S2199 | Phosphorylation | Uniprot | |
Y2202 | Phosphorylation | Uniprot | |
K2207 | Ubiquitination | Uniprot | |
K2248 | Ubiquitination | Uniprot | |
K2266 | Ubiquitination | Uniprot | |
K2303 | Ubiquitination | Uniprot | |
S2310 | Phosphorylation | Uniprot | |
K2318 | Ubiquitination | Uniprot | |
K2406 | Ubiquitination | Uniprot | |
K2413 | Ubiquitination | Uniprot | |
K2421 | Ubiquitination | Uniprot | |
K2431 | Ubiquitination | Uniprot | |
K2440 | Ubiquitination | Uniprot | |
K2505 | Ubiquitination | Uniprot | |
K2515 | Ubiquitination | Uniprot | |
K2589 | Ubiquitination | Uniprot | |
S2592 | Phosphorylation | Uniprot | |
K2643 | Methylation | Uniprot | |
K2643 | Ubiquitination | Uniprot | |
K2655 | Ubiquitination | Uniprot | |
K2657 | Ubiquitination | Uniprot | |
K2710 | Ubiquitination | Uniprot | |
T2751 | Phosphorylation | Uniprot | |
S2761 | Phosphorylation | Q13535 (ATR) | Uniprot |
K2789 | Ubiquitination | Uniprot | |
K2803 | Ubiquitination | Uniprot | |
S2812 | Phosphorylation | Uniprot | |
K2848 | Ubiquitination | Uniprot | |
Y2969 | Phosphorylation | Uniprot | |
K2992 | Ubiquitination | Uniprot | |
S2996 | Phosphorylation | Q13315 (ATM) | Uniprot |
K3004 | Ubiquitination | Uniprot | |
K3016 | Acetylation | Uniprot | |
K3053 | Ubiquitination | Uniprot |
翻译修饰 - Q13315 作为激酶
Substrate | Site | Source |
---|---|---|
O00255-2 (MEN1) | S394 | Uniprot |
O14757 (CHEK1) | S317 | Uniprot |
O14757 (CHEK1) | S345 | Uniprot |
O15111 (CHUK) | S473 | Uniprot |
O15151 (MDM4) | S342 | Uniprot |
O15151 (MDM4) | S367 | Uniprot |
O15151 (MDM4) | S403 | Uniprot |
O15355 (PPM1G) | S183 | Uniprot |
O15360 (FANCA) | S1449 | Uniprot |
O43504 (LAMTOR5) | S26 | Uniprot |
O43683 (BUB1) | S314 | Uniprot |
O60934 (NBN) | S278 | Uniprot |
O60934 (NBN) | S343 | Uniprot |
O60934 (NBN) | S397 | Uniprot |
O60934 (NBN) | S615 | Uniprot |
O75150 (RNF40) | S114 | Uniprot |
O75150 (RNF40) | S819 | Uniprot |
O75150 (RNF40) | S853 | Uniprot |
O75943-3 (RAD17) | S470 | Uniprot |
O75943-3 (RAD17) | S480 | Uniprot |
O75943-4 (RAD17) | S549 | Uniprot |
O75943-4 (RAD17) | S559 | Uniprot |
O75943-2 (RAD17) | S635 | Uniprot |
O75943-2 (RAD17) | S645 | Uniprot |
O75943 (RAD17) | S646 | Uniprot |
O75943-1 (RAD17) | S656 | Uniprot |
O94916 (NFAT5) | S1197 | Uniprot |
O94916 (NFAT5) | S1247 | Uniprot |
O94916 (NFAT5) | S1367 | Uniprot |
O95071 (UBR5) | S174 | Uniprot |
O95071 (UBR5) | S191 | Uniprot |
O95071 (UBR5) | S1532 | Uniprot |
O95071 (UBR5) | S1679 | Uniprot |
O95071 (UBR5) | S2586 | Uniprot |
O95863 (SNAI1) | S100 | Uniprot |
O96017 (CHEK2) | S19 | Uniprot |
O96017 (CHEK2) | T26 | Uniprot |
O96017 (CHEK2) | S28 | Uniprot |
O96017-12 (CHEK2) | S33 | Uniprot |
O96017-1 (CHEK2) | S35 | Uniprot |
O96017 (CHEK2) | S50 | Uniprot |
O96017 (CHEK2) | T68 | Uniprot |
O96017 (CHEK2) | S357 | Uniprot |
O96028 (NSD2) | S102 | Uniprot |
P00519 (ABL1) | S446 | Uniprot |
P00519-2 (ABL1) | S465 | Uniprot |
P04637-1 (TP53) | S9 | Uniprot |
P04637 (TP53) | S15 | Uniprot |
P04637-1 (TP53) | S20 | Uniprot |
P04637-1 (TP53) | S33 | Uniprot |
P04637-1 (TP53) | S37 | Uniprot |
P04637 (TP53) | S46 | Uniprot |
P08047 (SP1) | S56 | Uniprot |
P08047 (SP1) | S101 | Uniprot |
P12956 (XRCC6) | S27 | Uniprot |
P12956 (XRCC6) | S33 | Uniprot |
P15336 (ATF2) | S490 | Uniprot |
P15336 (ATF2) | S498 | Uniprot |
P15927 (RPA2) | T21 | Uniprot |
P15927 (RPA2) | S23 | Uniprot |
P15927 (RPA2) | S29 | Uniprot |
P16104 (H2AFX) | S140 | Uniprot |
P16220-2 (CREB1) | S97 | Uniprot |
P16220 (CREB1) | T100 | Uniprot |
P16220-2 (CREB1) | S107 | Uniprot |
P16220 (CREB1) | S111 | Uniprot |
P16220-1 (CREB1) | S121 | Uniprot |
P16220 (CREB1) | S133 | Uniprot |
P20823 (HNF1A) | S249 | Uniprot |
P23025 (XPA) | S173 | Uniprot |
P23025 (XPA) | S196 | Uniprot |
P25205 (MCM3) | S535 | Uniprot |
P25205 (MCM3) | S728 | Uniprot |
P27707 (DCK) | S74 | Uniprot |
P35637 (FUS) | S42 | Uniprot |
P38398-3 (BRCA1) | S284 | Uniprot |
P38398-6 (BRCA1) | S320 | Uniprot |
P38398-3 (BRCA1) | S353 | Uniprot |
P38398-3 (BRCA1) | S420 | Uniprot |
P38398-3 (BRCA1) | S438 | Uniprot |
P38398-8 (BRCA1) | S1142 | Uniprot |
P38398-7 (BRCA1) | S1189 | Uniprot |
P38398-8 (BRCA1) | S1283 | Uniprot |
P38398-7 (BRCA1) | S1330 | Uniprot |
P38398-8 (BRCA1) | S1340 | Uniprot |
P38398-8 (BRCA1) | S1376 | Uniprot |
P38398-7 (BRCA1) | S1387 | Uniprot |
P38398-8 (BRCA1) | S1410 | Uniprot |
P38398 (BRCA1) | S1423 | Uniprot |
P38398-1 (BRCA1) | S1457 | Uniprot |
P38398 (BRCA1) | S1466 | Uniprot |
P38398-8 (BRCA1) | S1477 | Uniprot |
P38398-8 (BRCA1) | S1495 | Uniprot |
P38398 (BRCA1) | S1497 | Uniprot |
P38398 (BRCA1) | S1524 | Uniprot |
P38398-1 (BRCA1) | S1542 | Uniprot |
P40692 (MLH1) | S406 | Uniprot |
P41236 (PPP1R2) | S44 | Uniprot |
P46379 (BAG6) | S26 | Uniprot |
P46379 (BAG6) | S218 | Uniprot |
P46527 (CDKN1B) | S140 | Uniprot |
P49917 (LIG4) | S199 | Uniprot |
P49959-2 (MRE11) | S264 | Uniprot |
P49959 (MRE11) | S676 | Uniprot |
P49959 (MRE11) | S678 | Uniprot |
P50542 (PEX5) | S141 | Uniprot |
P51532 (SMARCA4) | S721 | Uniprot |
P54132 (BLM) | T99 | Uniprot |
P54132 (BLM) | T122 | Uniprot |
P54274 (TERF1) | S219 | Uniprot |
P54274 (TERF1) | S367 | Uniprot |
P55072 (VCP) | S326 | Uniprot |
P55957 (BID) | S78 | Uniprot |
P60484 (PTEN) | S113 | Uniprot |
P60484 (PTEN) | T398 | Uniprot |
P63151 (PPP2R2A) | S400 | Uniprot |
P78527 (PRKDC) | T2609 | Uniprot |
P78527 (PRKDC) | S2612 | Uniprot |
P78527 (PRKDC) | T2638 | Uniprot |
P78527 (PRKDC) | T2647 | Uniprot |
Q00987 (MDM2) | S386 | Uniprot |
Q00987 (MDM2) | S395 | Uniprot |
Q00987-11 (MDM2) | S401 | Uniprot |
Q00987 (MDM2) | S429 | Uniprot |
Q01094 (E2F1) | S31 | Uniprot |
Q01844 (EWSR1) | T79 | Uniprot |
Q03111 (MLLT1) | S394 | Uniprot |
Q03111 (MLLT1) | S398 | Uniprot |
Q04206 (RELA) | S547 | Uniprot |
Q07021 (C1QBP) | S150 | Uniprot |
Q09472 (EP300) | S106 | Uniprot |
Q12888 (TP53BP1) | S6 | Uniprot |
Q12888-1 (TP53BP1) | S25 | Uniprot |
Q12888 (TP53BP1) | S29 | Uniprot |
Q12888 (TP53BP1) | T302 | Uniprot |
Q12888-1 (TP53BP1) | S784 | Uniprot |
Q12888 (TP53BP1) | S831 | Uniprot |
Q12888 (TP53BP1) | S1219 | Uniprot |
Q12888 (TP53BP1) | S1778 | Uniprot |
Q13263 (TRIM28) | S824 | Uniprot |
Q13315 (ATM) | S367 | Uniprot |
Q13315 (ATM) | S440 | Uniprot |
Q13315 (ATM) | T1885 | Uniprot |
Q13315 (ATM) | S1893 | Uniprot |
Q13315 (ATM) | S1981 | Uniprot |
Q13315 (ATM) | S1987 | Uniprot |
Q13315 (ATM) | S2996 | Uniprot |
Q13362 (PPP2R5C) | S520 | Uniprot |
Q13541 (EIF4EBP1) | S8 | Uniprot |
Q13541 (EIF4EBP1) | S94 | Uniprot |
Q13541 (EIF4EBP1) | S112 | Uniprot |
Q14161 (GIT2) | T195 | Uniprot |
Q14161 (GIT2) | S384 | Uniprot |
Q14191 (WRN) | S1141 | Uniprot |
Q14191 (WRN) | S1292 | Uniprot |
Q14676 (MDC1) | T4 | Uniprot |
Q14676 (MDC1) | T98 | Uniprot |
Q14676 (MDC1) | T719 | Uniprot |
Q14683 (SMC1A) | S957 | Uniprot |
Q14683 (SMC1A) | S966 | Uniprot |
Q14694 (USP10) | T42 | Uniprot |
Q14694 (USP10) | S337 | Uniprot |
Q14839 (CHD4) | S1349 | Uniprot |
Q15648 (MED1) | S816 | Uniprot |
Q15648 (MED1) | S872 | Uniprot |
Q15648 (MED1) | S874 | Uniprot |
Q15648 (MED1) | S887 | Uniprot |
Q15648 (MED1) | S953 | Uniprot |
Q15648 (MED1) | S1134 | Uniprot |
Q15648 (MED1) | S1141 | Uniprot |
Q15648 (MED1) | S1147 | Uniprot |
Q15797 (SMAD1) | S239 | Uniprot |
Q15831 (STK11) | T363 | Uniprot |
Q15831 (STK11) | T367 | Uniprot |
Q15910-2 (EZH2) | S734 | Uniprot |
Q16204 (CCDC6) | T434 | Uniprot |
Q16665 (HIF1A) | S696 | Uniprot |
Q5TZA2-2 (CROCC) | S922 | Uniprot |
Q5UIP0 (RIF1) | S1851 | Uniprot |
Q5VTR2 (RNF20) | S172 | Uniprot |
Q5VTR2 (RNF20) | S522 | Uniprot |
Q5VTR2 (RNF20) | S545 | Uniprot |
Q5XUX0 (FBXO31) | S278 | Uniprot |
Q6PCD5 (RFWD3) | S46 | Uniprot |
Q6PCD5 (RFWD3) | S63 | Uniprot |
Q6UWZ7 (ABRAXAS1) | S404 | Uniprot |
Q6UWZ7 (ABRAXAS1) | S406 | Uniprot |
Q70CQ2 (USP34) | S718 | Uniprot |
Q70CQ2 (USP34) | S1751 | Uniprot |
Q7L7X3 (TAOK1) | T643 | Uniprot |
Q7L7X3 (TAOK1) | T785 | Uniprot |
Q7L7X3 (TAOK1) | S990 | Uniprot |
Q7LG56 (RRM2B) | S72 | Uniprot |
Q7Z6Z7 (HUWE1) | S927 | Uniprot |
Q7Z6Z7 (HUWE1) | S2339 | Uniprot |
Q7Z6Z7 (HUWE1) | S2636 | Uniprot |
Q7Z6Z7 (HUWE1) | S3377 | Uniprot |
Q7Z6Z7 (HUWE1) | S3695 | Uniprot |
Q7Z6Z7 (HUWE1) | S3797 | Uniprot |
Q86U86 (PBRM1) | S948 | Uniprot |
Q8IUQ4 (SIAH1) | S19 | Uniprot |
Q8IW19 (APLF) | S116 | Uniprot |
Q8IY92 (SLX4) | S1138 | Uniprot |
Q8IY92 (SLX4) | S1271 | Uniprot |
Q8IY92 (SLX4) | S1631 | Uniprot |
Q8IY92 (SLX4) | S1716 | Uniprot |
Q8N0Z6 (TTC5) | S203 | Uniprot |
Q8N680 (ZBTB2) | S115 | Uniprot |
Q8NHY2 (COP1) | S387 | Uniprot |
Q8TAQ2 (SMARCC2) | S969 | Uniprot |
Q8TAQ5 (ZNF420) | S68 | Uniprot |
Q92547 (TOPBP1) | S492 | Uniprot |
Q92547 (TOPBP1) | S554 | Uniprot |
Q92547 (TOPBP1) | S853 | Uniprot |
Q92547 (TOPBP1) | T1062 | Uniprot |
Q92547 (TOPBP1) | S1138 | Uniprot |
Q92630 (DYRK2) | T106 | Uniprot |
Q92630 (DYRK2) | S442 | Uniprot |
Q92878 (RAD50) | S635 | Uniprot |
Q92945 (KHSRP) | S132 | Uniprot |
Q92945 (KHSRP) | S274 | Uniprot |
Q92945 (KHSRP) | S670 | Uniprot |
Q969H0 (FBXW7) | S26 | Uniprot |
Q96J02-2 (ITCH) | S161 | Uniprot |
Q96RL1 (UIMC1) | S205 | Uniprot |
Q96RL1 (UIMC1) | S402 | Uniprot |
Q96RU2 (USP28) | S67 | Uniprot |
Q96RU2 (USP28) | S495 | Uniprot |
Q96RU2 (USP28) | S714 | Uniprot |
Q96RU2 (USP28) | S720 | Uniprot |
Q96SD1-1 (DCLRE1C) | T91 | Uniprot |
Q96SD1-2 (DCLRE1C) | T131 | Uniprot |
Q96SD1-3 (DCLRE1C) | T136 | Uniprot |
Q96SD1-1 (DCLRE1C) | T251 | Uniprot |
Q96SD1-2 (DCLRE1C) | S396 | Uniprot |
Q96SD1-3 (DCLRE1C) | S401 | Uniprot |
Q96SD1-2 (DCLRE1C) | S414 | Uniprot |
Q96SD1-2 (DCLRE1C) | S418 | Uniprot |
Q96SD1-3 (DCLRE1C) | S419 | Uniprot |
Q96SD1-3 (DCLRE1C) | S423 | Uniprot |
Q96SD1-2 (DCLRE1C) | S433 | Uniprot |
Q96SD1-3 (DCLRE1C) | S438 | Uniprot |
Q96SD1-2 (DCLRE1C) | S442 | Uniprot |
Q96SD1-3 (DCLRE1C) | S447 | Uniprot |
Q96SD1 (DCLRE1C) | S503 | Uniprot |
Q96SD1 (DCLRE1C) | S516 | Uniprot |
Q96SD1-2 (DCLRE1C) | S525 | Uniprot |
Q96SD1-3 (DCLRE1C) | S530 | Uniprot |
Q96SD1-1 (DCLRE1C) | S534 | Uniprot |
Q96SD1-1 (DCLRE1C) | S538 | Uniprot |
Q96SD1-1 (DCLRE1C) | S553 | Uniprot |
Q96SD1-1 (DCLRE1C) | S562 | Uniprot |
Q96SD1 (DCLRE1C) | S645 | Uniprot |
Q96T60 (PNKP) | S114 | Uniprot |
Q96T60 (PNKP) | S126 | Uniprot |
Q99504 (EYA3) | S266 | Uniprot |
Q99638 (RAD9A) | S272 | Uniprot |
Q99708-3 (RBBP8) | S664 | Uniprot |
Q99708-3 (RBBP8) | S745 | Uniprot |
Q99801 (NKX3-1) | T134 | Uniprot |
Q99801 (NKX3-1) | T166 | Uniprot |
Q9BQ15 (NABP2) | T117 | Uniprot |
Q9BXS6 (NUSAP1) | S124 | Uniprot |
Q9BXW9-1 (FANCD2) | S222 | Uniprot |
Q9BXW9 (FANCD2) | T691 | Uniprot |
Q9BXW9 (FANCD2) | S717 | Uniprot |
Q9BXW9-1 (FANCD2) | S1257 | Uniprot |
Q9BXW9 (FANCD2) | S1401 | Uniprot |
Q9BXW9 (FANCD2) | S1404 | Uniprot |
Q9BXW9 (FANCD2) | S1407 | Uniprot |
Q9H2K8 (TAOK3) | S324 | Uniprot |
Q9H2K8 (TAOK3) | S359 | Uniprot |
Q9H2K8 (TAOK3) | S551 | Uniprot |
Q9H3D4 (TP63) | S477 | Uniprot |
Q9H3D4 (TP63) | S479 | Uniprot |
Q9H3D4 (TP63) | T491 | Uniprot |
Q9H3D4 (TP63) | S560 | Uniprot |
Q9H9Q4 (NHEJ1) | S251 | Uniprot |
Q9HB75 (PIDD1) | T788 | Uniprot |
Q9NQS1 (AVEN) | S135 | Uniprot |
Q9NQS1 (AVEN) | S308 | Uniprot |
Q9NS23-2 (RASSF1) | S131 | Uniprot |
Q9NS23 (RASSF1) | S135 | Uniprot |
Q9NS91 (RAD18) | S403 | Uniprot |
Q9NUW8 (TDP1) | S81 | Uniprot |
Q9NUW8 (TDP1) | S91 | Uniprot |
Q9NUW8 (TDP1) | S365 | Uniprot |
Q9NUW8 (TDP1) | S563 | Uniprot |
Q9NVI1 (FANCI) | S556 | Uniprot |
Q9NVI1 (FANCI) | S559 | Uniprot |
Q9NVI1 (FANCI) | S730 | Uniprot |
Q9NVI1 (FANCI) | S972 | Uniprot |
Q9NVI1 (FANCI) | S1121 | Uniprot |
Q9NY61 (AATF) | S189 | Uniprot |
Q9UBU7 (DBF4) | T449 | Uniprot |
Q9UBU7 (DBF4) | S502 | Uniprot |
Q9UBU7 (DBF4) | S539 | Uniprot |
Q9UER7 (DAXX) | S564 | Uniprot |
Q9UQE7 (SMC3) | S1083 | Uniprot |
Q9UQR1 (ZNF148) | S202 | Uniprot |
Q9Y2K7 (KDM2A) | T632 | Uniprot |
Q9Y4E8 (USP15) | S678 | Uniprot |
Q9Y6D9 (MAD1L1) | S214 | Uniprot |
Q9Y6K9 (IKBKG) | S85 | Uniprot |
研究背景
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.
Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase. During the late stages of DNA damage response, dephosphorylated following deacetylation by SIRT7, leading to ATM deactivation.
Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP60. Deacetylated by SIRT7 during the late stages of DNA damage response, promoting ATM dephosphorylation and subsequent deactivation.
Nucleus. Cytoplasmic vesicle.
Note: Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Homodimer. Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2, ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with DDX1. Interacts with BRAT1.
The FATC domain is required for interaction with KAT5.
Belongs to the PI3/PI4-kinase family. ATM subfamily.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Genetic Information Processing > Replication and repair > Homologous recombination.
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
文献引用
Application: WB Species: Mouse Sample: GC-1 cells
Application: WB Species: mouse Sample: testis
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