产品: Dynamin 1 抗体
货号: AF4096
描述: Rabbit polyclonal antibody to Dynamin 1
应用: WB
反应: Human, Mouse, Rat
分子量: 100kd; 97kD(Calculated).
蛋白号: Q05193
RRID: AB_2835366

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
Dynamin 1 Antibody detects endogenous levels of total Dynamin 1.
RRID:
AB_2835366
引用格式: Affinity Biosciences Cat# AF4096, RRID:AB_2835366.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1;

抗原和靶标

免疫原:

A synthesized peptide derived from human Dynamin 1, corresponding to a region within C-terminal amino acids.

Uniprot:
基因/基因ID:
描述:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
序列:
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQASPSRPESPRPPFDL

翻译修饰 - Q05193 作为底物

Site PTM Type Enzyme
S46 Phosphorylation
S61 Phosphorylation
K113 Ubiquitination
S116 Phosphorylation
K206 Ubiquitination
T214 Phosphorylation
R217 Methylation
K223 Ubiquitination
Y231 Phosphorylation P12931 (SRC)
K257 Ubiquitination
S261 Phosphorylation
S264 Phosphorylation
R271 Methylation
S302 Phosphorylation
S306 Phosphorylation
S347 Phosphorylation
Y354 Phosphorylation
K376 Ubiquitination
T411 Phosphorylation
S433 Phosphorylation
S437 Phosphorylation
T438 Phosphorylation
T443 Phosphorylation
S512 Phosphorylation
K523 Ubiquitination
K598 Acetylation
S668 Phosphorylation
Y669 Phosphorylation
Y732 Phosphorylation
S774 Phosphorylation
T776 Phosphorylation
S777 Phosphorylation
S778 Phosphorylation P17252 (PRKCA)
T780 Phosphorylation Q00535 (CDK5)
S795 Phosphorylation Q13627 (DYRK1A)
S822 Phosphorylation
S851 Phosphorylation
S857 Phosphorylation Q13627 (DYRK1A)

研究背景

功能:

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

细胞定位:

Cytoplasm. Cytoplasm>Cytoskeleton.
Note: Microtubule-associated.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1. Interacts with AMPH, BIN1 AND SYNJ1 (By similarity).

蛋白家族:

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

· Organismal Systems > Nervous system > Synaptic vesicle cycle.

· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.

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