产品: CDKA1 / DOC1 抗体
货号: AF0309
描述: Rabbit polyclonal antibody to CDKA1 / DOC1
应用: WB IHC IF/ICC
反应: Human, Mouse
分子量: 20kDa; 12kD(Calculated).
蛋白号: O14519
RRID: AB_2833473

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
CDKA1 / DOC1 Antibody detects endogenous levels of total CDKA1 / DOC1.
RRID:
AB_2833473
引用格式: Affinity Biosciences Cat# AF0309, RRID:AB_2833473.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CDK2 A1; CDK2 associated protein 1; CDK2-associated protein 1; CDK2AP1; CDKA1; CDKA1_HUMAN; Cyclin dependent kinase 2 associated protein 1; Cyclin-dependent kinase 2-associated protein 1; Deleted in oral cancer 1; DOC 1; DOC 1 related protein; DOC 1R; DOC-1; DOC1; DOC1R; DORC1; p12DOC 1; Putative oral cancer suppressor; ST19;

抗原和靶标

免疫原:

A synthesized peptide derived from human CDKA1 / DOC1, corresponding to a region within C-terminal amino acids.

Uniprot:
基因/基因ID:
描述:
CDK2AP1 Belongs to the CDK2AP family.
序列:
MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

翻译修饰 - O14519 作为底物

Site PTM Type Enzyme
S24 Phosphorylation
S46 Phosphorylation Q14164 (IKBKE)
S84 Phosphorylation
K85 Ubiquitination
S86 Phosphorylation

研究背景

功能:

specific inhibitor of the cell-cycle kinase CDK2.

翻译修饰:

Phosphorylated in vitro by IKBKE at Ser-46.

亚基结构:

Homodimer. Interacts with monomeric unphosphorylated CDK2 (By similarity). Interacts with CDK2AP2.

蛋白家族:

Belongs to the CDK2AP family.

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