产品: Histone H1.0 抗体
货号: DF3073
描述: Rabbit polyclonal antibody to Histone H1.0
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep
分子量: 20 KD; 21kD(Calculated).
蛋白号: P07305
RRID: AB_2835456

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 50ul RMB¥ 1250 现货
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 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(88%), Bovine(88%), Sheep(88%)
克隆:
Polyclonal
特异性:
Histone H1.0 Antibody detects endogenous levels of total Histone H1.0.
RRID:
AB_2835456
引用格式: Affinity Biosciences Cat# DF3073, RRID:AB_2835456.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

H1 histone family member 0; H1(0); H10; H10_HUMAN; h1f0; H1FV; Histone H1''; Histone H1(0); Histone H1.0; Histone H10; Histone H5; MGC5241; N-terminally processed;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
序列:
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
88
Bovine
88
Sheep
88
Horse
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P07305 作为底物

Site PTM Type Enzyme
M1 Acetylation
T2 Acetylation
T2 Phosphorylation
S5 Phosphorylation
S7 Phosphorylation
K12 Methylation
K14 Acetylation
K27 Acetylation
K27 Ubiquitination
K40 Ubiquitination
K52 Acetylation
K52 Ubiquitination
Y58 Phosphorylation
K59 Acetylation
K59 Methylation
K59 Ubiquitination
S66 Phosphorylation
K82 Methylation
K82 Ubiquitination
T84 Phosphorylation
K85 Ubiquitination
S90 Phosphorylation
S92 Phosphorylation
K102 Methylation
K108 Acetylation
K108 Methylation
T119 Phosphorylation
K121 Acetylation
S124 Phosphorylation
T141 Phosphorylation
K149 Ubiquitination
T153 Phosphorylation
K155 Methylation
K161 Acetylation
S171 Phosphorylation

研究背景

功能:

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

翻译修饰:

Phosphorylated on Ser-17 in RNA edited version.

ADP-ribosylated on Ser-104 in response to DNA damage.

细胞定位:

Nucleus. Chromosome.
Note: The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the histone H1/H5 family.

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