产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3092, RRID:AB_2835475.
展开/折叠
80K-H protein; AGE-binding receptor 2; AGE-R2; G19P1; GLU2B_HUMAN; Glucosidase 2 subunit beta; Glucosidase II beta subunit; Glucosidase II subunit beta; Hepatocystin; PCLD; PKCSH; PLD1; PRKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain; Protein kinase C substrate 80 Kda protein; Protein kinase C substrate 80K-H; Protein kinase C substrate, 80 Kda protein;
抗原和靶标
- P14314 GLU2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLPLLLLLPMCWAVEVKRPRGVSLTNHHFYDESKPFTCLDGSATIPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICENTCKEKGRKERESLQQMAEVTREGFRLKKILIEDWKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEEAPPPLSPPQPASPAEEDKMPPYDEQTQAFIDAAQEARNKFEEAERSLKDMEESIRNLEQEISFDFGPNGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKLGGSPTSLGTWGSWIGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETMVTSTTEPSRCEYLMELMTPAACPEPPPEAPTEDDHDEL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P14314 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S24 | Phosphorylation | Uniprot | |
| K83 | Methylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| T134 | O-Glycosylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| R177 | Methylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| T287 | O-Glycosylation | Uniprot | |
| S293 | O-Glycosylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S349 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| Y423 | Phosphorylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| T448 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| K459 | Acetylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| T494 | Phosphorylation | Uniprot | |
| S498 | Phosphorylation | Uniprot |
研究背景
Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Endoplasmic reticulum.
Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC (By similarity).
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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