产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3127, RRID:AB_2835504.
展开/折叠
80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK alpha; DGK-alpha; dgkA; DGKA_HUMAN; Diacylglycerol kinase alpha; Diacylglycerol kinase, alpha 80kDa; Diglyceride kinase alpha; MGC12821; MGC42356; OTTHUMP00000242836; OTTHUMP00000242955; OTTHUMP00000244046;
抗原和靶标
- P23743 DGKA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS
翻译修饰 - P23743 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K18 | Ubiquitination | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| T24 | Phosphorylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| Y218 | Phosphorylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| Y335 | Phosphorylation | P06239 (LCK) , P12931 (SRC) | Uniprot |
| S348 | Phosphorylation | Uniprot | |
| K353 | Acetylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| K484 | Acetylation | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| Y623 | Phosphorylation | Uniprot | |
| K634 | Ubiquitination | Uniprot | |
| T637 | Phosphorylation | Uniprot | |
| K643 | Ubiquitination | Uniprot | |
| K652 | Ubiquitination | Uniprot | |
| Y669 | Phosphorylation | Uniprot | |
| T670 | Phosphorylation | Uniprot | |
| K681 | Ubiquitination | Uniprot | |
| K691 | Ubiquitination | Uniprot | |
| K714 | Ubiquitination | Uniprot | |
| S735 | Phosphorylation | Uniprot |
研究背景
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.
Lymphocytes and oligodendroglial cells.
Monomer.
Belongs to the eukaryotic diacylglycerol kinase family.
研究领域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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