| 产品: | GRK3 抗体 |
| 货号: | DF3165 |
| 描述: | Rabbit polyclonal antibody to GRK3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 80 KD; 80kD(Calculated). |
| 蛋白号: | P35626 |
| RRID: | AB_2835541 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3165, RRID:AB_2835541.
展开/折叠
ADRBK2; Adrenergic, beta, receptor kinase 2; ARBK2_HUMAN; BARK2; Beta adrenergic receptor kinase 2; Beta ARK 2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; EC 2.7.11.15; G protein coupled receptor kinase 3; G-protein-coupled receptor kinase 3; GRK3;
抗原和靶标
- P35626 ARBK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P35626 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K45 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| T353 | Phosphorylation | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| S487 | Phosphorylation | Uniprot | |
| K494 | Ubiquitination | Uniprot | |
| K497 | Ubiquitination | Uniprot | |
| K507 | Ubiquitination | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| T524 | Phosphorylation | Uniprot | |
| Y526 | Phosphorylation | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| Y564 | Phosphorylation | Uniprot | |
| T612 | Phosphorylation | Uniprot | |
| K625 | Acetylation | Uniprot | |
| K628 | Acetylation | Uniprot | |
| K628 | Ubiquitination | Uniprot | |
| K644 | Ubiquitination | Uniprot | |
| K645 | Ubiquitination | Uniprot | |
| K652 | Ubiquitination | Uniprot | |
| S670 | Phosphorylation | Uniprot | |
| T672 | Phosphorylation | Uniprot | |
| S685 | Phosphorylation | Uniprot |
翻译修饰 - P35626 作为激酶
| Substrate | Site | Source |
|---|---|---|
| P07550 (ADRB2) | S355 | Uniprot |
| P07550 (ADRB2) | S356 | Uniprot |
| P21731-2 (TBXA2R) | S239 | Uniprot |
| P21731-2 (TBXA2R) | S357 | Uniprot |
| P30411 (BDKRB2) | S366 | Uniprot |
| P30411 (BDKRB2) | S373 | Uniprot |
| P30411 (BDKRB2) | S375 | Uniprot |
| P30874 (SSTR2) | S341 | Uniprot |
| P30874 (SSTR2) | S343 | Uniprot |
| P35372 (OPRM1) | T182 | Uniprot |
| P41146 (OPRL1) | S363 | Uniprot |
| P51681 (CCR5) | S336 | Uniprot |
| P51681 (CCR5) | S337 | Uniprot |
| P51681 (CCR5) | S342 | Uniprot |
| P51681 (CCR5) | S349 | Uniprot |
研究背景
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
Ubiquitinated.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Sensory system > Olfactory transduction.
限制条款
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