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| 产品: | CD253 抗体 |
| 货号: | DF3194 |
| 描述: | Rabbit polyclonal antibody to CD253 |
| 应用: | WB IF/ICC |
| 文献验证: | WB |
| 反应: | Human |
| 预测: | Horse, Sheep, Rabbit |
| 分子量: | 30 KD; 33kD(Calculated). |
| 蛋白号: | P50591 |
| RRID: | AB_2835553 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3194, RRID:AB_2835553.
展开/折叠
Apo 2 ligand; APO 2L; Apo-2 ligand; Apo-2L; APO2L; CD253; CD253 antigen; Chemokine tumor necrosis factor ligand superfamily member 10; Protein TRAIL; TL2; TNF Related Apoptosis Inducing Ligand; TNF related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNF10_HUMAN; TNFSF10; TRAIL; Tumor necrosis factor (ligand) family member 10; Tumor Necrosis Factor (ligand) Superfamily Member 10; Tumor necrosis factor apoptosis inducing ligand splice variant delta; Tumor necrosis factor ligand superfamily member 10;
抗原和靶标
- P50591 TNF10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50591 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K106 | Ubiquitination | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| T135 | Phosphorylation | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot |
研究背景
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Tyrosine phosphorylated by PKDCC/VLK.
Cell membrane>Single-pass type II membrane protein. Secreted.
Note: Exists both as membrane-bound and soluble form.
Widespread; most predominant in spleen, lung and prostate.
Homotrimer. One TNFSF10 homotrimer interacts with three TNFSF10A mononers. One TNFSF10 homotrimer interacts with three TNFSF10B mononers.
Belongs to the tumor necrosis factor family.
研究领域
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
文献引用
Application: WB Species: human Sample: LS174T cells
限制条款
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