FXR2 Antibody - #DF3195

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产品: FXR2 抗体
货号: DF3195
描述: Rabbit polyclonal antibody to FXR2
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 75kD, 95kD, 115kD; 74kD(Calculated).
蛋白号: P51116
RRID: AB_2835554

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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相关下载
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
FXR2 Antibody detects endogenous levels of total FXR2.
RRID:
AB_2835554
引用格式: Affinity Biosciences Cat# DF3195, RRID:AB_2835554.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FMR1L2; Fragile X mental retardation 1 like 2; Fragile X mental retardation autosomal homolog 2; Fragile X mental retardation gene autosomal homolog 2; Fragile X mental retardation syndrome related protein 2; Fragile X mental retardation syndrome-related protein 2; FXR 2; FXR2; FXR2 PEN; FXR2_HUMAN; FXR2P; Human fragile X mental retardation syndrome related protein FXR2 mRNA complete cds;

抗原和靶标

免疫原:
Uniprot:

P51116(FXR2_HUMAN) >>Visit HPA database.

基因/基因ID:
FXR2(9513)
序列:
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P51116 作为底物

Site PTM Type Enzyme
S6 Phosphorylation
S21 Phosphorylation
Y26 Phosphorylation
T70 Phosphorylation
Y113 Phosphorylation
S192 Phosphorylation
K205 Ubiquitination
K256 Ubiquitination
K305 Ubiquitination
K312 Ubiquitination
K320 Ubiquitination
T350 Phosphorylation
R393 Methylation
S397 Phosphorylation
R399 Methylation
S404 Phosphorylation
Y409 Phosphorylation
S410 Phosphorylation
T411 Phosphorylation
S414 Phosphorylation
S415 Phosphorylation
S416 Phosphorylation
S418 Phosphorylation
R432 Methylation
R434 Methylation
R436 Methylation
S446 Phosphorylation
S447 Phosphorylation
S450 Phosphorylation
T451 Phosphorylation
S453 Phosphorylation
T455 Phosphorylation
S457 Phosphorylation
R488 Methylation
R490 Methylation
S500 Phosphorylation
S504 Phosphorylation
S506 Phosphorylation
S509 Phosphorylation
K512 Ubiquitination
Y519 Phosphorylation
S520 Phosphorylation
T524 Phosphorylation
S525 Phosphorylation
S533 Phosphorylation
S548 Phosphorylation
T553 Phosphorylation
R557 Methylation
S566 Phosphorylation
T572 Phosphorylation
S580 Phosphorylation
T598 Phosphorylation
S601 Phosphorylation
S603 Phosphorylation
T610 Phosphorylation
Y614 Phosphorylation
S620 Phosphorylation
S634 Phosphorylation
S637 Phosphorylation
S639 Phosphorylation
S645 Phosphorylation
S647 Phosphorylation
S654 Phosphorylation

研究背景

功能:

RNA-binding protein.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with FMR1. Interacts with FXR1. Interacts with TDRD3. Interacts with HABP4. Interacts with CYFIP2 but not with CYFIP1 (By similarity).

(Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-FXR2 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.

蛋白家族:

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.

Belongs to the FMR1 family.

研究领域

· Genetic Information Processing > Translation > RNA transport.

文献引用

1). Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis. PHYTOMEDICINE (PubMed: 35605478) [IF=7.9]

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