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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3195, RRID:AB_2835554.
展开/折叠
FMR1L2; Fragile X mental retardation 1 like 2; Fragile X mental retardation autosomal homolog 2; Fragile X mental retardation gene autosomal homolog 2; Fragile X mental retardation syndrome related protein 2; Fragile X mental retardation syndrome-related protein 2; FXR 2; FXR2; FXR2 PEN; FXR2_HUMAN; FXR2P; Human fragile X mental retardation syndrome related protein FXR2 mRNA complete cds;
抗原和靶标
- P51116 FXR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P51116 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| Y26 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| T350 | Phosphorylation | Uniprot | |
| R393 | Methylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| R399 | Methylation | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| Y409 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| R432 | Methylation | Uniprot | |
| R434 | Methylation | Uniprot | |
| R436 | Methylation | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| T451 | Phosphorylation | Uniprot | |
| S453 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| R488 | Methylation | Uniprot | |
| R490 | Methylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| Y519 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| T524 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| T553 | Phosphorylation | Uniprot | |
| R557 | Methylation | Uniprot | |
| S566 | Phosphorylation | Uniprot | |
| T572 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| T598 | Phosphorylation | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| T610 | Phosphorylation | Uniprot | |
| Y614 | Phosphorylation | Uniprot | |
| S620 | Phosphorylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot | |
| S639 | Phosphorylation | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| S647 | Phosphorylation | Uniprot | |
| S654 | Phosphorylation | Uniprot |
研究背景
RNA-binding protein.
Cytoplasm.
Interacts with FMR1. Interacts with FXR1. Interacts with TDRD3. Interacts with HABP4. Interacts with CYFIP2 but not with CYFIP1 (By similarity).
(Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-FXR2 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.
The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.
Belongs to the FMR1 family.
研究领域
· Genetic Information Processing > Translation > RNA transport.
文献引用
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