产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3238, RRID:AB_2835618.
展开/折叠
FLJ96772; KIME_HUMAN; LH receptor mRNA binding protein; LRBP; Mevalonate kinase 1; Mevalonate kinase; Mevalonic aciduria; MK; mvk; MVLK; POROK3;
抗原和靶标
- Q03426 KIME_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q03426 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
T37 | Phosphorylation | Uniprot | |
S45 | Phosphorylation | Uniprot | |
K59 | Ubiquitination | Uniprot | |
K90 | Ubiquitination | Uniprot | |
K179 | Ubiquitination | Uniprot | |
K187 | Ubiquitination | Uniprot | |
K220 | Ubiquitination | Uniprot | |
S227 | Phosphorylation | Uniprot | |
K238 | Ubiquitination | Uniprot | |
K330 | Ubiquitination | Uniprot | |
K345 | Ubiquitination | Uniprot |
研究背景
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
Cytoplasm. Peroxisome.
Homodimer.
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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